683226-92-8

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 343338-28-3 (S)-2-methylpropane-2-sulfinamide 

Downstream Products

• 870074-94-5 2-Methyl-propane-2-sulfinic acid [(1R,2R)-3-benzyloxy-2-hydroxy-1-(4-methoxy-phenyl)-propyl]-amide 
• 220736-25-4 (4R,5R)-cytoxazone 
• 461644-55-3 (4R,5R)-5-benzyloxymethyl-4-(4-methoxyphenyl)oxazolidin-2-one 
• 820965-96-6 (1R,2R)-1,2-Bis-(4-methoxy-phenyl)-ethane-1,2-diamine; compound with GENERIC INORGANIC NEUTRAL COMPONENT 
• 1010692-91-7 dimethyl [(S_S,R)-(+)-(tert-butylsulfinylamino)(4-methoxyphenyl)methyl]phosphonate 
• 1023378-00-8 (S)-2-methyl-propane-2-sulfinic acid [(S)-cyclohexa-2,5-dienyl-(4-methoxy-phenyl)-methyl]-amide 
• 1023377-79-8 (S)-2-methyl-propane-2-sulfinic acid [(S)-(R)-cyclohexa-2,4-dienyl-(4-methoxyphenyl)-methyl]-amide 
• 1174267-78-7 1-[(1,1-dimethylethyl)sulfinyl]-2-(4-methoxyphenyl)aziridine 
• 1316220-52-6 ethyl (2S,3S)-1-((S)-tert-butylsulfinyl)-3-(4-methoxyphenyl)aziridine-2-carboxylate 

Relevant academic research and scientific papers

Synthesis of Sulfinimines by Direct Condensation of Sulfinamides with Aldehydes Using Cs2CO3 as an Activating and Dehydrating Reagent

Chiral sulfinimines were prepared from chiral sulfinamides and aldehydes in CH2Cl2 in the presence of cesium carbonate as an amine-activating and dehydrating reagent.

RAS INHIBITORS

The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

Synthesis of enantiomerically pure aryl, hetero aryl and alkyl sulfinimides catalyzed by recyclable tungstophosphoric acid

A simple and efficient procedure was developed for the preparation of a variety of aryl, hetero aryl and alkyl N-sulfinylimines (2b-2u) with excellent yields (85–94%) using tungstophosphoric acid as catalyst. Also, this new synthetic protocol features hig

Triisopropyl borate mediated N-sulfinyl imine formation

Triisopropyl borate effects the condensation of aldehydes with sulfinamides to give N-sulfinyl imines. The reaction is amenable to 1°, 2°, and 3° alkyl aldehydes, as well as aryl, heteroaryl, and α,β-unsaturated aldehydes. In addition to tert-butanesulfin

A General Method for Imine Formation Using B(OCH2CF3)3

Tris(2,2,2-trifluoroethyl)borate [B(OCH2CF3)3] was found to be a mild and general reagent for the formation of a variety of imines by condensation of amides or amines with carbonyl compounds. N-Sulfinyl, N-toluenesulfonyl,

Synthesis of chiral aziridines through decarboxylative generation of sulfur ylides and their reaction with chiral sulfinyl imines

Reaction of sulfur ylides with a series of aryl substituted chiral nonracemic sulfinyl imines afforded the corresponding aziridines in good yields with good stereoselectivity. The sulfur ylides were generated by the thermally induced decarboxylation of carboxymethylsulfonium betaines. A drop in the diastereomeric ratio was observed when going from electron-deficient to electron-releasing aryl substituted imines. S-Methylene aziridinations involving the decarboxylation of carboxymethylsulfonium betaine functionality complements existing technologies with the advantages of the reaction protocol, levels of conversion, and scope.

Desymmetrization of metallated cyclohexadienes with chiral N-tert-butanesulfinyl imines

This communication describes the desymmetrization of various achiral metallated cyclohexadienes with a series of chiral N-tert-butanesulfinyl imines. Depending on the metal used, either the symmetrical diene (dicyclohexadienyl- zinc) or the desymmetrized

A new and convenient asymmetric synthesis of α-amino- and α-alkyl-α-aminophosphonic acids using N-tert-butylsulfinyl imines as chiral auxiliaries

Nucleophilic addition of dialkyl phosphites to N-tert-butylsulfinyl aldimines or ketimines occurs successfully at room temperature with potassium carbonate as base to afford α-amino- and α-alkyl-α-amino-N- (tert-butylsulfinyl)phosphonates in good to excel

KHSO4-mediated condensation reactions of tert-butanesulfinamide with aldehydes. Preparation of tert-butanesulfinyl aldimines

Optically pure tert-butanesulfinyl aldimines 1 were prepared by direct condensation of chiral tert-butanesulfinamide 3 with aldehydes 2 in high yields in the presence of KHSO4. The main advantage of KHSO4 is that it is applicable to the condensation reactions of a variety of aldehydes, including electron deficient and electron rich (hetereo)aromatic aldehydes, as well as aliphatic aldehydes.

A room-temperature protocol for the rhodium(I)-catalyzed addition of arylboron compounds to sulfinimines

(Chemical Equation Presented) The addition of organoboronic acids to chiral sulfinimines proceeds under mild conditions at room temperature, using Rh(I) catalysis in the absence of external phosphine ligands. Clean reaction only occurs in the presence of