683276-63-3

Upstream product

• 86884-89-1 (R)-2-methylglycidol 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 86884-90-4 (S)-2-methylglycidol 
• 513-42-8 3-hydroxy-2-methyl-1-propene 

Downstream Products

• 1116653-76-9 (R)-tert-butyl (4-(benzyloxy)-1-iodonaphthalen-2-yl)(oxiran-2-ylmethyl)carbamate 
• 683276-72-4 (R)-1-(2-methyl-2-oxiranylmethyl)-2-(4-nitrophenylthio)imidazole 
• 683276-51-9 (R)-1-(2-methyl-2-oxiranylmethyl)-4-nitro-2-(4-nitrophenylthio)imidazole 
• 681490-93-7 2-chloro-1-{[(2R)-2-methyloxiran-2-yl]methyl}-4-nitro-1H-imidazole 

Relevant academic research and scientific papers

ANTI-PULMONARY TUBERCULOSIS NITROIMIDAZOLE DERIVATIVE

Disclosed is a substituted nitroimidazole derivative, which is mainly used for treating related diseases caused by mycobacterial infections, such as Mycobacterium tuberculosis, especially being suitable for diseases caused by resistant Mycobacterium tuberculosis.

Using an asymmetric flow reactor sharples

PROBLEM TO BE SOLVED: To provide a method for efficiently progressing a Sharpless asymmetric epoxidation even without adding molecular sieves. SOLUTION: The method for producing an optically active epoxyalcohol compound includes mixing an allyl alcohol compound, a titanium tetraalkoxide in a catalytic amount, an optically active tartaric acid ester in a catalytic amount, and an oxidizing agent, in a solvent by using a flow-type reactor (flow reactor). The oxidizing agent is preferably tert-butyl hydroperoxide or cumene hydroperoxide. COPYRIGHT: (C)2013,JPOandINPIT

1-SUBSTITUTED 4-NITROIMIDAZOLE COMPOUND AND PROCESS FOR PRODUCING THE SAME

The present invention relates to a 1-substituted-4-nitroimidazole compound represented by the general formula (1) or a salt thereof, (wherein R is a hydrogen atom, a lower alkoxy group-substituted lower alkyl group, a phenyl-lower alkoxy group-substituted lower alkyl group, a cyano-substituted lower alkyl group, a phenyl-lower alkyl group which may have lower alkoxy groups as the substituents in the phenyl ring or a group of the formula -CH2RA; X is a halogen atom or a group of the formula -S(O)n-R1) and method for preparing the same. The compound of the formula (1) is a useful compound as an intermediate for synthesis of various pharmaceutical and agricultural chemicals, particularly, as intermediates for antitubercular agents.