68332-33-2

Usage

Uses

Used in Pharmaceutical Research:
3-(3-IODO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is used as a building block for the synthesis of various pharmaceuticals. Its unique structure and reactivity make it a valuable component in the development of new drugs and medicinal compounds.
Used in Chemical Research:
In the field of chemical research, 3-(3-IODO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is employed as a substrate in various chemical reactions, such as oxidation, reduction, and acid-base reactions. Its versatility allows researchers to explore its potential applications in different chemical processes and syntheses.
Used in Organic Synthesis:
3-(3-IODO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER is utilized as a key intermediate in the synthesis of other organic compounds. Its presence in the molecular structure can impart specific properties and reactivity, making it a useful component in the creation of complex organic molecules for various applications.

InChI:InChI=1/C11H11IO3/c1-2-15-11(14)7-10(13)8-4-3-5-9(12)6-8/h3-6H,2,7H2,1H3

Upstream product

• 1071-46-1 hydrogen ethyl malonate 
• 1711-10-0 3-iodobenzoyl chloride 
• 58313-23-8 3-iodobenzoic acid methyl ester 
• 14452-30-3 3'-iodoacetophenone 
• 105-58-8 Diethyl carbonate 
• 141-78-6 ethyl acetate 

Downstream Products

• 745079-22-5 tert-butyl 3-(3-iodophenyl)-3-oxopropanoate 
• 98305-65-8 C₁₀H₈IN₃O 
• 1265602-81-0 C₁₉H₂₀O₃ 
• 1270083-87-8 3-(3-iodophenyl)-1-(pyridin-2-yl)-1H-pyrazol-5-ol 
• 1452793-97-3 4-[1-aminomethylidene]-2-benzothiazol-2-yl-5-(3-iodophenyl)-2,4-dihydropyrazol-3-one 
• 1452794-04-5 2-benzothiazol-2-yl-5-(3-iodophenyl)-4-[1-dimethylaminomethylidene]-2,4-dihydropyrazol-3-one 
• 1452794-02-3 2-benzothiazol-2-yl-5-(3-iodophenyl)-1,2-dihydropyrazol-3-one 
• 1148118-66-4 2-(3'-iodobenzoyl)-3H-benzo[f]chromen-3-one 
• 76531-99-2 2-Amino-5-iodo-6-(3-iodo-phenyl)-3H-pyrimidin-4-one 
• 76519-09-0 2-Amino-5-bromo-6-(3-iodo-phenyl)-3H-pyrimidin-4-one 
• 76519-08-9 2-Amino-5-chloro-6-(3-iodo-phenyl)-3H-pyrimidin-4-one 

Relevant academic research and scientific papers

Amide/Ester Cross-Coupling via C-N/C-H Bond Cleavage: Synthesis of β-Ketoesters

Activated primary, secondary, and tertiary amides were coupled with enolizable esters in the presence of LiHMDS to obtain good yields of β-ketoesters at room temperature. Notably, this protocol provides an efficient, mild, and high chemoselectivity method

Design, Synthesis, and Biochemical Characterization of Non-Native Antagonists of the Pseudomonas aeruginosa Quorum Sensing Receptor LasR with Nanomolar IC50 Values

Quorum sensing (QS), a bacterial cell-to-cell communication system mediated by small molecules and peptides, has received significant interest as a potential target to block infection. The common pathogen Pseudomonas aeruginosa uses QS to regulate many of its virulence phenotypes at high cell densities, and the LasR QS receptor plays a critical role in this process. Small molecule tools that inhibit LasR activity would serve to illuminate its role in P. aeruginosa virulence, but we currently lack highly potent and selective LasR antagonists, despite considerable research in this area. V-06-018, an abiotic small molecule discovered in a high-throughput screen, represents one of the most potent known LasR antagonists but has seen little study since its initial report. Herein, we report a systematic study of the structure-activity relationships (SARs) that govern LasR antagonism by V-06-018. We synthesized a focused library of V-06-018 derivatives and evaluated the library for bioactivity using a variety of cell-based LasR reporter systems. The SAR trends revealed by these experiments allowed us to design probes with 10-fold greater potency than that of V-06-018 and 100-fold greater potency than other commonly used N-acyl-l-homoserine lactone (AHL)-based LasR antagonists, along with high selectivities for LasR. Biochemical experiments to probe the mechanism of antagonism by V-06-018 and its analogues support these compounds interacting with the native ligand-binding site in LasR and, at least in part, stabilizing an inactive form of the protein. The compounds described herein are the most potent and efficacious antagonists of LasR known and represent robust probes both for characterizing the mechanisms of LuxR-type QS and for chemical biology research in general in the growing QS field.

THERAPEUTIC COMPOUNDS AND USES THEREOF

The present invention relates to compounds useful as inhibitors of one or more histone demethylses, such as KDM5. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said