68337-44-0

Upstream product

• 18871-66-4 N,N-dimethylacetamide dimethyl acetal 
• 40207-03-2 p-Anisidinothioformyl-hydrazin 
• 124-42-5 acetamidine hydrochloride 
• 71-36-3 butan-1-ol 
• 502703-95-9 2-acetyl-N-(4-methoxyphenyl)hydrazinecarbothioamide 

Downstream Products

• 743452-47-3 [4-(4-methoxy-phenyl)-5-methyl-4H-[1,2,4]triazol-3-ylsulfanyl]-acetic acid 
• 68377-29-7 4-(4-methoxyphenyl)-3-methyl-4H-1,2,4-triazole 

Relevant academic research and scientific papers

Synthesis and biological evaluations of sulfanyltriazoles as novel HIV-1 non-nucleoside reverse transcriptase inhibitors

A novel sulfanyltriazole was discovered as an HIV-1 non-nucleoside reverse transcriptase inhibitor via HTS using a cell-based assay. Chemical modifications and molecular modeling studies were carried out to establish its SAR and understand its interactions with the enzyme. These modifications led to the identification of sulfanyltriazoles with low nanomolar potency for inhibiting HIV-1 replication and promising activities against selected NNRTI resistant mutants. These novel and potent sulfanyltriazoles could serve as advanced leads for further optimization.

The Synthesis of 4-Substituted-4H-1,2,4-triazole-3-thiols and 3-Methylthio-4-substituted-4H-1,2,4-triazoles

The synthesis of 4-substituted-4H-1,2,4-triazole-3-thiols and 3-methylthio-4-substituted-4H-1,2,4-triazoles by the condensation of 4-substituted-3-thiosemicarbazides with dimethylformamide dimethyl acetal or dimethylacetamide dimethyl acetal is described.A discussion of the mechanistic pathway is included.

Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles

Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles, useful as antifungal and antibacterial agents.