502703-95-9Relevant academic research and scientific papers
Antimicrobial and Physicochemical Characterizations of Thiosemicarbazide and S-Triazole Derivatives
Kusmierz, Edyta,Siwek, Agata,Kosikowska, Urszula,Malm, Anna,Plech, Tomasz,Wrobel, Andrzej,Wujec, Monika
, p. 1539 - 1545 (2015/10/29)
Two series of thiosemicarbazide derivatives and three series of s-triazole derivatives have been synthesized. All of these compounds were tested for their in vitro antibacterial activity against Gram-positive and Gram-negative bacterial strains. Among tested thiosemicarbazide derivatives, the best bioactivity was detected for two 1-formylthiosemicarbazides with 3-/4-tolyl substitution (1 l, 1 m) (MICs range between 31.25 and 250 μg/mL). All tested s-triazole derivatives exhibited lower antibacterial activity than their acyclic precursors.
A novel and facile environmentally benign oxidative electrocyclization of acylthiosemicarbazone into biodynamic 1,3,4-oxadiazoles
Sharma, Laxmi Kant,Singh, Sushma,Siddiqui,Singh
experimental part, p. 155 - 161 (2012/03/26)
A novel, facile and green oxidative electrocyclization of the acylthiosemicarbazone into 5-substituted-2-amino(substituted)-1,3,4-oxadiazoles at platinum electrode using acetonitrile as non-aqueous solvent and lithium perchlorate as supporting electrolyte
Synthesis and biological evaluations of sulfanyltriazoles as novel HIV-1 non-nucleoside reverse transcriptase inhibitors
Wang, Zhiwei,Wu, Baogen,Kuhen, Kelli L.,Bursulaya, Badry,Nguyen, Truc N.,Nguyen, Deborah G.,He, Yun
, p. 4174 - 4177 (2007/10/03)
A novel sulfanyltriazole was discovered as an HIV-1 non-nucleoside reverse transcriptase inhibitor via HTS using a cell-based assay. Chemical modifications and molecular modeling studies were carried out to establish its SAR and understand its interactions with the enzyme. These modifications led to the identification of sulfanyltriazoles with low nanomolar potency for inhibiting HIV-1 replication and promising activities against selected NNRTI resistant mutants. These novel and potent sulfanyltriazoles could serve as advanced leads for further optimization.
