6837-00-9

Upstream product

• 67-56-1 methanol 
• 6836-98-2 3-phenyldihydrofuran-2-one 
• 6837-26-9 4-hydroxy-2-phenyl-butyric acid 
• 6836-99-3 (RS)-4-Bromo-2-phenylbutanoic acid 
• 126503-01-3 dianion de l'acide phenylacetique 

Downstream Products

• 130504-09-5 C₁₀H₁₁⁽²⁾HO₂ 
• 130504-08-4 C₁₁H₁₃⁽²⁾HO₂ 

Relevant academic research and scientific papers

A micromethod for the determination of the configuration of secondary alcohols by kinetic deduction. Employment of mass spectrography

An optically active secondary alcohol is treated by an equimolecular mixture of (+)-2-phenylbutyric and (-)-2-phenyl-4-d-butyric anhydrides. The configuration of the carbon atom bearing the OH group is deduced from the relative heights of peaks m/z 120 and 119 observed in the mass spectra of the resulting diastereoisomeric esters.

PREPARATION OF ALPHA-ARYL GAMMA-BUTYROLACTONES

This appliciation discloses a process for preparing a lactone of general formula (I), where R is an optionally substituted phenyl group or an optionally substituted mono-or bicyclic heteroaryl radical which process comprises reacting an anion of a malonate of formula (II) with an ethylene compound of formula (III) Y--CH 2--CH 2 OZ, to give a compound of formula (IV) and hydrolysing the compound of formula (IV) to give a lactone of formula (I). The lactones are of use as intermediates for preparing 5-HT 1A binding agents. STR1