A micromethod for the determination of the configuration of secondary alcohols by kinetic deduction. Employment of mass spectrography

Article abstract of DOI:10.1016/S0040-4039(00)94678-1

An optically active secondary alcohol is treated by an equimolecular mixture of (+)-2-phenylbutyric and (-)-2-phenyl-4-d-butyric anhydrides. The configuration of the carbon atom bearing the OH group is deduced from the relative heights of peaks m/z 120 and 119 observed in the mass spectra of the resulting diastereoisomeric esters.