68402-81-3

Basic information

• Product Name: (6R,7R)-7-(Benzoylamino)-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester
• Synonyms: (6R,7R)-7-(Benzoylamino)-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester;Intermediate 1 of Latamoxef Sodium
• CAS NO: 68402-81-3
• Molecular Formula: C₃₁H₂₈N₆O₆S
• Molecular Weight: 612.65562
• EINECS: 1533716-785-6
• Mol File: 68402-81-3.mol

Chemical Properties

• Appearance: /
• Density: 1.42
• CAS DataBase Reference: (6R,7R)-7-(Benzoylamino)-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (6R,7R)-7-(Benzoylamino)-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester(68402-81-3)
• EPA Substance Registry System: (6R,7R)-7-(Benzoylamino)-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester(68402-81-3)

Safety Data

• Hazardous Substances Data: 68402-81-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Cefroxadine is used as an antibiotic for treating bacterial infections. It works by inhibiting the growth of bacteria, making it effective against a wide range of pathogens. It is commonly prescribed for respiratory, urinary, and skin infections.
Used in Healthcare Settings:
In healthcare settings, Cefroxadine is used to combat bacterial infections and prevent the spread of diseases. It is an essential tool for healthcare professionals in managing and treating various types of infections, ensuring the well-being of patients.

Upstream product

• 66510-99-4 (6R,7R)-benzhydryl-7-amino-7-methoxy-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 98-88-4 benzoyl chloride 
• 51138-06-8 sodium 1-methyl-1H-tetrazole-5-thiolate 
• 68402-51-7 (6R,7R)-7-Benzoylamino-3-chloromethyl-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzyl ester 

Downstream Products

• 106163-00-2 (2S,3S,6R,7R)-3-Chloro-7-methoxy-8-oxo-7-phenylacetylamino-3-(2,2,2-trichloro-acetylcarbamoyloxymethyl)-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester 
• 106162-96-3 (2S,3S,6R,7R)-3-Chloro-3-(2-chloro-acetoxymethyl)-7-methoxy-8-oxo-7-phenylacetylamino-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester 
• 106162-91-8 (2S,3R,6R,7R)-3-Methanesulfonyl-7-methoxy-3-methoxymethyl-8-oxo-7-phenylacetylamino-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester 
• 106162-97-4 (6R,7R)-3-(2-Chloro-acetoxymethyl)-7-methoxy-8-oxo-7-phenylacetylamino-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 106163-01-3 diphenylmethyl 7β-(phenylacetamido)-7α-methoxy-3-<(carbamoyloxy)methyl>-1-oxadethia-3-cephem-4-carboxylate 
• 106162-90-7 (2S,3R,6R,7R)-7-Methoxy-3-methoxymethyl-3-methylsulfanyl-8-oxo-7-phenylacetylamino-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester 
• 106162-99-6 diphenylmethyl 7β-(phenylacetamido)-7α-methoxy-3-(acetoxymethyl)-1-oxadethia-3-cephem-4-carboxylate 
• 106162-89-4 (2S,3S,6R,7R)-3-Chloromethyl-7-methoxy-3-methylsulfanyl-8-oxo-7-phenylacetylamino-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester 
• 106162-94-1 diphenylmethyl 7β-(phenylacetamido)-7α-methoxy-3-(cyanomethyl)-1-oxadethia-3-cephem-4-carboxylate 
• 106162-92-9 diphenylmethyl 7β-(phenylacetamido)-7α-methoxy-3-(methoxymethyl)-1-oxadethia-3-cephem-4-carboxylate 
• 106162-95-2 (2S,3R,6R,7R)-3-Chloro-3-hydroxymethyl-7-methoxy-8-oxo-7-phenylacetylamino-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester 
• 106162-93-0 diphenylmethyl 7β-(phenylacetamido)-7α-methoxy-3-hydroxy-1-oxadethia-3-cephem-4-carboxylate 
• 106162-98-5 diphenylmethyl 7β-(phenylacetamido)-7α-methoxy-3-(hydroxymethyl)-1-oxadethia-3-cephem-4-carboxylate 
• 68314-02-3 diphenylmethyl 7β-(phenylacetamido)-7α-methoxy-3-methylene-1-oxadethia-3-cephem-4α-carboxylate 

Relevant articles and documents

Synthesis and structure-activity relationships of a new class of 1-oxacephem-based human chymase inhibitors

1-Oxacephem derivatives were synthesized and evaluated as a novel series of chymase inhibitors. Structure-activity relationship studies of 1-oxacephems led to compound 34, which exhibited 6 nM inhibition of human chymase and high selectivity for human chymase compared to other serine enzymes. (C) 2000 Elsevier Science Ltd.

STEREOCONTROLLED, STRAIGHTFORWARD SYNTHESIS OF 3-SUBSTITUTED METHYL 7α-METHOXY-1-OXACEPHEMS

Stereocontrolled and industrially feasible synthesis of a new antibiotic 1a and related derivates, which is characterized by using all the carbon atoms of the penicillin skeleton, is described.