68404-19-3

Basic information

• Product Name: N,N-dipropylprop-2-enamide
• CAS NO: 68404-19-3
• Molecular Formula: C₉H₁₇NO
• Molecular Weight: 155.2374
• Mol File: 68404-19-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 257°C at 760 mmHg
• Flash Point: 107.5°C
• Density: 0.879g/cm³
• Vapor Pressure: 0.0149mmHg at 25°C
• Refractive Index: 1.447
• CAS DataBase Reference: N,N-dipropylprop-2-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dipropylprop-2-enamide(68404-19-3)
• EPA Substance Registry System: N,N-dipropylprop-2-enamide(68404-19-3)

Safety Data

• Hazardous Substances Data: 68404-19-3(Hazardous Substances Data)

Usage

General Description

N,N-dipropylprop-2-enamide is a chemical compound with the molecular formula C9H17NO. It is a derivative of prop-2-enamide, also known as acrylamide, and is characterized by the presence of two propyl groups attached to the nitrogen atom. This chemical is commonly used as a reactive intermediate in organic synthesis and serves as a building block for the preparation of various chemical compounds. It is also utilized in the production of polymers and plastics. However, N,N-dipropylprop-2-enamide is known to be toxic and can cause skin and respiratory irritation upon exposure. Therefore, proper safety measures and handling precautions are necessary when working with this compound.

Upstream product

• 142-84-7 di-n-propylamine 
• 79-10-7 acrylic acid 
• 814-68-6 acryloyl chloride 

Downstream Products

• 1224594-05-1 3-nitro-N,N-dipropylisoxazole-5-carboxamide 
• 1224594-11-9 4,4,4-trinitro-N,N-dipropylbutanamide 
• 1114-59-6 N,N-dipropylpropionamide 

Relevant articles and documents

Clickable coupling of carboxylic acids and amines at room temperature mediated by SO2F2: A significant breakthrough for the construction of amides and peptide linkages

The construction of amide bonds and peptide linkages is one of the most fundamental transformations in all life processes and organic synthesis. The synthesis of structurally ubiquitous amide motifs is essential in the assembly of numerous important molecules such as peptides, proteins, alkaloids, pharmaceutical agents, polymers, ligands and agrochemicals. A method of SO2F2-mediated direct clickable coupling of carboxylic acids with amines was developed for the synthesis of a broad scope of amides in a simple, mild, highly efficient, robust and practical manner (>110 examples, >90% yields in most cases). The direct click reactions of acids and amines on a gram scale are also demonstrated using an extremely easy work-up and purification process of washing with 1 M aqueous HCl to provide the desired amides in greater than 99% purity and excellent yields.

METHOD FOR PRODUCING N-SUBSTITUTED (METH)ACRYLAMIDE

PROBLEM TO BE SOLVED: To provide an industrial method for efficiently producing a high-purity N-substituted (meth)acrylamide in a short time even under mild reaction conditions, which uses (meth)acrylic acid as a starting material and generates only water as a byproduct. SOLUTION: There is provided a method for producing an N-substituted (meth)acrylamide to obtain an objective compound, N-substituted (meth)acrylamide by the step of: reacting a (meth)acrylic and an amine compound to synthesize an aminopropionic acid derivative; then adding an inorganic material composed mainly of silica as a catalyst and performing amidation with the same amine compound to obtain an aminopropionic acid derivative; and subsequently eliminating an amine by the thermal decomposition reaction. COPYRIGHT: (C)2015,JPOandINPIT