68406-47-3

Usage

Uses

Used in Pharmaceutical Industry:
5-chloro-N-phenylbenzene-1,2-diamine is used as a reagent for the synthesis of dihydrobenzodiazepinediones. These compounds serve as inhibitors of HIV-1 capsid assembly reverse transcriptase, which is a crucial enzyme in the replication process of the HIV virus. By inhibiting this enzyme, the compound can potentially slow down or stop the progression of the virus, making it a valuable tool in the development of antiretroviral therapies.

InChI:InChI=1/C12H11ClN2/c13-9-6-7-11(14)12(8-9)15-10-4-2-1-3-5-10/h1-8,15H,14H2

Upstream product

• 4340-77-6 4-chloroazobenzene 
• 949-88-2 1-(4-chlorophenyl)-2-phenylhydrazine 
• 201230-82-2 carbon monoxide 
• 25781-92-4 5-chloro-2-nitro-N-phenylaniline 
• 7647-01-0 hydrogenchloride 
• 67-56-1 methanol 
• 7664-93-9 sulfuric acid 
• 108-86-1 bromobenzene 
• 1635-61-6 5-chloro-2-nitroaniline 
• 700-37-8 4-chloro-2-fluoro-nitrobenzene 
• 62-53-3 aniline 

Downstream Products

• 96048-77-0 6-chloro-1-phenyl-1H-benzimidazole 
• 3942-95-8 8-chloro-10-phenyl-10H-benzo[g]pteridine-2,4-dione 
• 22316-55-8 N-desmethylclobazam 
• 36985-45-2 8-chloro-4-(dimethylamino)-1,3-dihydro-1-phenyl-2H-1,5-benzodiazepin-2-one 
• 22316-47-8 clobazam 
• 1329991-47-0 C₂₀H₂₁ClN₄O 
• 1329990-25-1 C₁₇H₁₃ClN₄O 
• 1329990-87-5 C₁₇H₁₃ClN₄O 
• 1267635-28-8 C₁₈H₁₅ClN₄O 
• 1267634-98-9 C₂₀H₂₀ClN₃O₃ 
• 38224-97-4 3-(butylamino-methylene)-8-chloro-1-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione 
• 1393181-15-1 [(S)-1-(6-chloro-1-phenyl-1H-benzoimidazol-2-yl)ethyl]-(9H-purin-6-yl)amine 
• 1393176-79-8 (S)-1-(6-chloro-1-phenyl-1H-benzoimidazol-2-yl)ethylamine 
• 1393176-77-6 [(S)-1-(6-chloro-1-phenyl-1H-benzoimidazol-2-yl)ethyl]carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

COMPOUND FOR ORGANIC OPTOELECTRONIC DEVICE, COMPOSITION FOR ORGANIC OPTOELECTRONIC DEVICE, ORGANIC OPTOELECTRONIC DEVICE AND DISPLAY DEVICE

The compound according to claim 1, wherein the compound is represented by the following Formula. The present invention relates to a composition for an organic optoelectric device, an organic optoelectric device, and a display device. The details of Formula 1 are as defined in the specification.

Utilization of a Hydrogen Source from Renewable Lignocellulosic Biomass for Hydrogenation of Nitroarenes

Exploring of hydrogen source from renewable biomass, such as glucose in alkaline solution, for hydrogenation reactions had been studied since 1860s. According to proposed pathway, only small part of hydrogen source in glucose was utilized. Herein, the utilization of a hydrogen source from renewable lignocellulosic biomass, one of the most abundant renewable sources in nature, for a hydrogenation reaction is described. The hydrogenation is demonstrated by reduction of nitroarenes to arylamines in up to 95 % yields. Mechanism studies suggest that the hydrogenation occurs via a hydrogen transformation pathway.

Method being suitable for industrially producing clobazam

The invention discloses a method of industrially producing clobazam and belongs to the technical field of medicine synthesis. With 5-chloro-2-nitrobenzidine as an initial raw material, the method includes the steps of reduction with a nano heavy metal granular catalyst, catalytic condensation with Lewis acid, methylation, and purification to prepare the clobazam that satisfies clinical medicinal requirement. The method solves the problems of heavy toxicity and serious pollution in the prior art, is beneficial to labor protection and reduces production cost, and improves product quality and economic benefit.

PROCESS FOR PREPARING CLOBAZAM USING NOVEL INTERMEDIATES

Processes for preparation of 7-chloro-1-methyl-5-phenyl-1,5-dihydro- benzo[b][1,4]diazepine-2,4-dione (Clobazam) are provided. The present invention also relates to the novel intermediates and its use in preparation of clobazam.

Nanoscale Fe2O3-based catalysts for selective hydrogenation of nitroarenes to anilines

Production of anilines - key intermediates for the fine chemical, agrochemical, and pharmaceutical industries - relies on precious metal catalysts that selectively hydrogenate aryl nitro groups in the presence of other easily reducible functionalities. Herein, we report convenient and stable iron oxide (Fe2O3) - based catalysts as a more earth-abundant alternative for this transformation. Pyrolysis of iron-phenanthroline complexes on carbon furnishes a unique structure in which the active Fe2O 3 particles are surrounded by a nitrogen-doped carbon layer. Highly selective hydrogenation of numerous structurally diverse nitroarenes (more than 80 examples) proceeded in good to excellent yield under industrially viable conditions.

HETEROCYCLIC COMPOUNDS AND METHODS OF USE

Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

DERIVATIVES OF 1-PHENYL-1,5-DIHYDRO-BENZO[B] [1.4]DIAZEPINE-2.4-DIONE AS INHIBITORS OF HIV REPLICATION

Compounds of formula (I) wherein m, R1, R2, R3, X and Y are defined herein, are useful as inhibitors of HIV replication.

ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE

The present invention is directed to aryl sulfamide derivatives of formula (I): or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

A mild, one-pot synthesis of disubstituted benzimidazoles from 2-nitroanilines

A one-pot synthesis of disubstituted benzimidazoles from 2-nitroanilines is described. Hydrogenation of N-substituted 2-nitroanilines with palladium on carbon as catalyst in the presence of trimethyl orthoformate and catalytic pyridinium p-toluenesulfonate (PPTS) at room temperature provided good to excellent yields of the corresponding disubstituted benzimidazoles.