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Usage

Uses

Used in Pharmaceutical Industry:
N-(1H-benzimidazol-2-ylsulfanyl)cyclohexanamine, or rabeprazole, is used as a medication for the treatment of gastrointestinal conditions. It serves as a proton pump inhibitor, reducing stomach acid production and providing relief for conditions such as gastroesophageal reflux disease (GERD), ulcers, and other related disorders. Its long-lasting effects, when taken in delayed-release tablet form, make it a practical and effective choice for managing these health issues.

Upstream product

• 108-91-8 cyclohexylamine 
• 98154-63-3 2-ethyl-1,2,4-thiadiazolo[4,5-a]benzimidazole-3(2H)-one 
• 538-75-0 dicyclohexyl-carbodiimide 
• 87504-17-4 2-cyclohexylbenzimidazo<1,2-d><1,2,4>thiadiazol-3(2H)-one 

Relevant academic research and scientific papers

Exchange, Elimination, and Ring Opening Reactions of 2,3-Dihydrobenzimidazothiadiazoles and 3H-Benzimidazodithiazoles

The reactions of benzimidazothiadiazol-3(2H)-ones (1) with isocyanates, isothiocyanates, carbon disulphide, aryl cyanates, acetylenedicarboxylates, and enamines, with exchange of the isocyanate component of (1), to give the corresponding condensed benzimidazole derivatives (1)-(6) are described.Under more severe conditions the 1-benzothiazol-2-yl-1,3-dihydrobenzimidazole-2-thiones (7) were obtained from aromatic isothiocyanates.Thermolysis of the thiadiazoles (1) led to the triazine derivative (12) with elimination of isocyanate and sulphur, and in the presence of phenols to the 2-aryloxybenzimidazoles (13).With amines and CH-acidic compounds, the S,N bond in compound (1) was cleaved to give benzimidazol-2-ylsulphenamides (14), and the ω-substituted methylthiobenzimidazoles (17) and (18).With cyanide ion, insertion into the S,N bond of compound (1) to furnish the thiadiazine (22) took place.The dithiazoles (2) were fragmented by amines to give 1,3-dihydrobenzimidazole-2-thione and guanidine with loss of sulphur; reaction with cyanide ion then gave the dibenzimidazothiadiazine (25).