6842-36-0

Upstream product

• 109-80-8 1.3-propanedithiol 
• 24396-24-5 2-(dimethoxymethyl)phenol 
• 89-95-2 2-methyl-benzyl alcohol 
• 55727-23-6 3‐(1,3-dithiane-2-yl)pentane-2,4-dione 
• 90-02-8 salicylaldehyde 
• 57529-04-1 2-chloro-1,3-dithiane 

Downstream Products

• 496043-47-1 2-[2'-tert-butyldimethylsilyloxyphenyl]-1,3-dithiane 
• 1416161-51-7 C₁₉H₂₄O₂Si 
• 1416161-41-5 C₂₀H₂₂O₃Si 
• 1416161-43-7 C₂₀H₂₂O₂Si 
• 68185-99-9 (2-hydroxybenzoyl)trimethylsilane 
• 1416161-44-8 C₁₉H₁₉FO₂Si 
• 1416161-15-3 C₁₃H₂₀O₂Si 
• 1416160-98-9 C₁₉H₂₀O₂Si 
• 1416161-16-4 C₂₀H₂₂O₃Si 
• 1416161-17-5 C₂₀H₂₂O₂Si 
• 1416161-18-6 C₁₉H₁₉FO₂Si 
• 1416161-24-4 C₁₉H₂₄O₂Si 
• 1416161-25-5 C₁₄H₁₈O₂Si 
• 1416161-26-6 C₁₇H₂₄O₂Si 

Relevant academic research and scientific papers

Asymmetric synthesis of photophore-containing lactisole derivatives to elucidate sweet taste receptors

Lactisole, which has a 2-phenoxy propionic acid skeleton, is well-known as an inhibitor of sweet taste receptors. We recently revealed some of the structure-activity relationships of the aromatic ring and chiral center of lactisole. Photoaffinity labeling

An expedient carbon–sulfur bond formation explored through the cellulose sulfonic acid (CSA) catalyzed dithioacetal protection of carbonyl compounds

A facile carbon–sulfur bond formation was observed through the cellulose sulfonic acid (CSA) catalyzed dithioacetal protection of carbonyl compounds. In a preliminary study, the synthesis and characterization of functionalized bio-polymer, cellulose sulph

Rh-Catalyzed domino synthesis of 4-hydroxy-3-methylcoumarins via branch-selective hydroacylation

A Rh-catalyzed domino synthesis of 4-hydroxy-3-methylcoumarins via branch-selective hydroacylation of acrylates and acrylamides using salicylaldehydes is described. This protocol under phosphine-free Rh-catalyzed conditions provided 4-hydroxy-3-methylcoum

A 2 - substituted - 1, 3 - dithiane derivative of the preparation method

The invention provides a preparation method of a 2-substituted-1,3-dithiane derivative. The preparation method comprises the following steps: adding 1,3-dithiane (CAS:505-23-7) and 1,2-dichloroethane (DCE) or dichloromethane (DCM) into a reaction bottle, adding N-chlorosuccinimide (NCS) under ice-bath condition, and stirring for 0.5-1 h to prepare a 2-chloro-1,3-dithiane solution; and adding an aldehyde or ketone compound and a lewis acid catalyst into the above solution, and reacting to prepare the 2-substituted-1,3-dithiane derivative. By using the 1,3-dithiane solid and different types of aldehyde and keto-carbonyl compounds as raw material and using one or more of ferric trichloride, boron trifluoride diethyl etherate, methanesulfonic acid, aluminum trichloride, ferrous chloride and nickel chloride as catalysts, preparation of the 2-substituted-1,3-dithiane derivative is realized. The catalysts used in the invention are cheap and easily available, dosage of the catalysts is low and pollution of the catalysts is little. The solid raw materials used in the invention can avoid use of fetid toxic 1,3-dimercaptopropane with strong volatility, and the purpose of protecting an experimenter's body and reducing environmental pollution is realized. In addition, the preparation method has advantages of mild reaction condition, high yield, simple operation and the like.

Visible-light promoted dithioacetalization of aldehydes with thiols under aerobic and photocatalyst-free conditions

A novel photocatalyst-free visible-light-mediated dithioacetalization of aldehydes and thiols has been developed. This protocol is operationally simple, mild and atom-economical, which provides an environmental benign access to dithioacetals at room temperature under aerobic conditions.

Preparing method of 2-substituted-1,3-dithiane derivative

The invention belongs to the technical field of organic synthesis, and particularly discloses a preparing method of a 2-substituted-1,3-dithiane derivative. The preparing method comprises the following steps of adding substrate aldehyde, 1,3-dimercaptopro

Thioacetalization of aldehydes and ketones catalyzed by hexabromoacetone

Protection of p-anisaldehydewith 1,3-propanedithiol under UV irradiation without a catalyst resulted in 87% yield of 1,3-dithiane in 20 min. Addition of hexabromoacetone further reduced the reaction time and UV irradiation also accelerated the formation o

Graphene oxide (GO)-catalyzed chemoselective thioacetalization of aldehydes under solvent-free conditions

An efficient method for the synthesis of open chain, cyclic, and unsymmetrical dithioacetals from aryl/hetero-aryl/aliphatic aldehydes is described. The reaction is performed using graphene oxide (GO) as the catalyst under solvent-free and aerobic conditions. High chemoselectivity is observed in the reaction as aryl/alkyl ketones do not give thioketals under the condition.

Solid-supported odorless reagents for the dithioacetalization of aldehydes and ketones

A solid supported, odorless reagent for the dithioacetalization of aldehydes and ketones has been developed. The new reagent provides the dimercaptoalkane equivalent in combination with stoichiometric amounts of immobilized acid and enables the formation of dithianes and dithiolanes from aldehydes without any additives in good to very good yields with high purities. The reaction is chemoselective for aldehydes, but ketones can be reacted to the corresponding dithioketals if an additional Lewis acid such as BF3is added.

Fe-catalyzed direct dithioacetalization of aldehydes with 2-chloro-1,3-dithiane

Present methods to synthesize 1,3-dithiane molecules require either harsh reaction conditions or highly specialized reagents. We have developed a catalytic dithioacetalization process that directly gains access to the corresponding 1,3-dithianes using aldehydes and 2-chloro-1,3-dithiane in a highly efficient manner. This methodology is beneficial due to mildness of the reaction conditions, and the dithioacetaliation process results in good to excellent yields by using 15 mol % of an iron catalyst.