6842-62-2Relevant articles and documents
Method for preparing 3,4'-dichlorodiphenyl ether from difenoconazole isomer
-
Paragraph 0084; 0090-0093; 0099-0102; 0108-0110, (2021/04/28)
The invention relates to a method for preparing 3,4'-dichlorodiphenyl ether from a difenoconazole isomer. The preparation method comprises the steps of hydrolysis, a haloform reaction, a decarboxylation reaction and the like. According to the preparation method disclosed by the invention, 3,4'-dichlorodiphenyl ether can be efficiently prepared from the difenoconazole isomer. The method not only can effectively reduce solid wastes, turn the waste into the wealth, reduce production cost and improve the economic benefits, but also can be applied to synthesis of other drug intermediates.
Production device of 3, 4-dichlorodiphenyl ether
-
Paragraph 0005; 0028; 0036-0038, (2021/07/01)
The utility model relates to a production device of 3, 4-dichlorodiphenyl ether, which comprises a parachlorophenol head tank, an etherification synthesis kettle, a centrifugal mother liquor tank, an etherification desolventizing kettle, an etherification distillation kettle and a 3, 4-dichlorodiphenyl ether receiving tank which are sequentially connected, and the upper part of the etherification synthesis kettle is sequentially connected with a condenser and an etherification separated water receiving tank; a centrifugal transfer pump and a potassium chloride centrifugal machine are sequentially arranged on a connecting pipeline of the etherification synthesis kettle and the centrifugal mother liquor tank, the upper part of the etherification desolventizing kettle is sequentially connected with a condenser and an m-dichlorobenzene receiving tank, and the upper part of the etherification distillation kettle is sequentially connected with a condenser, a 3, 4-dichlorodiphenyl ether front fraction tank and a 3, 4-dichlorodiphenyl ether receiving tank. The production device disclosed by the utility model is simple in overall structure, all equipment is convenient to operate, and by arranging the condensing device, the centrifugal transfer pump, the centrifugal pump and the like, the production process is optimized, the production efficiency is improved, and the effects of low energy consumption and cost saving are realized.
Copper-mediated synthesis of mono- and dichlorinated diaryl ethers
?ermák, Jan K.,Církva, Vladimír
supporting information, p. 4185 - 4188 (2014/07/22)
An efficient synthesis of polychlorinated diphenyl ethers (PCDEs) using the Cu(OAc)2-catalyzed Chan-Lam coupling reaction is described. A library of all possible mono- and dichlorinated diphenyl ether congeners was prepared and characterized using MS, 1H, and 13C NMR spectroscopy, and Kovats retention indices. Our approach, using the optimized reaction conditions (i.e., reaction temperature, oxidizing atmosphere and base), significantly improves and simplifies the process compared to previously reported syntheses.