119446-68-3Relevant articles and documents
Triazole compound containing dioxolame and preparation method of intermediate of triazole compound
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, (2021/09/04)
The invention relates to a preparation method of a dioxolane-containing triazole compound and an intermediate thereof, and the method comprises the following steps: reacting a compound shown as a formula (V) with a compound shown as a formula (IV) in the presence of Lewis acid to prepare a compound shown as a formula (III); reacting the compound shown in the formula (III) with a compound shown in the formula (II) to prepare the compound shown in the formula (I). According to the technical scheme, a triazole group is introduced into 1H-1, 2, 4-triazole-1-acetic acid, generation of an isomer 1, 3, 4-triazole byproduct is avoided, the reaction yield is increased, and the method has the advantages of being simple and convenient in process route, few in reaction step, simple in process, low in production cost, environmentally friendly, green and safe; the post-treatment of the product only needs a simple solvent crystallization process, a nitric acid salifying method and a high-temperature distillation method do not need to be adopted, the requirements on equipment are reduced and the cost is reduced under the condition of improving the yield and content of the product, and the method is suitable for industrial production.
Method for converting 4 - H difenoconazole isomer into 1 - H-difenoconazole (by machine translation)
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, (2020/07/21)
A method for converting 4 - H-difenoconazole isomer into 1 - H-difenoconazole isomer to obtain an alcohol, 2) reaction of the alcohol and hydrobromic acid to obtain a bromide; 3) separating 1 difenoconazole and 4 - H) 1 - H) from the mixture of 4 - H-difenoconazole and 1 - H-difenoconazole isomer; 4) completely converting 4 - H-difenoconazole isomer into 4 - H-phenylene difenoconazole.) isomer is obtained by dissolving 1) difenoconazole and difenoconazole as a mixture in the presence of a base and a transition metal catalyst to obtain a mixture of difenoconazole and difenoconazole -4 4 - H 1 - H. The method not only can effectively reduce the solid waste problem 4 - H difenoconazole isomer, but also can convert the difenoconazole product into 1 - H difenoconazole product, so that the cost is reduced, the product yield is increased, and the economic benefit is improved. (by machine translation)
Synthetic process of difenoconazole
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, (2019/07/16)
The invention discloses a synthetic process of difenoconazole, comprising the steps of synthesizing 2,4-dichloroacetophenone through ionic liquid acylation using m-dichlorobenzene as a raw material; then synthesizing alpha-bromo-2,4-dichloroacetophenone through a green bromination method; subjecting the alpha-bromo-2,4-dichloroacetophenone and 1,2-propanediol to cyclization to generate a ketal compound that is 2-(2,4-dichlorophenyl)-2-bromomethyl-4-methyl-1,3-dioxolane; subjecting the ketal compound and 1,2,4-triazole potassium to condensation to generate 1-[[2-(2,4-dichlorophenyl)-4-methyl-1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazole; and finally subjecting the 1-[[2-(2,4-dichlorophenyl)-4-methyl-1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazole and parachlorophenol to etherification to obtain the difenoconazole. The process has advantages of easily available raw materials, a high reaction conversion ratio, few byproducts, capability of being friendly to production environment and a low cost.