684249-70-5

Usage

Chemical class

Piperidinecarboxylates

Structure

Contains a piperidine ring with a carboxylate group

Substituent

4-[(4-bromo-3-fluorophenyl)oxy] at the 1-position

Application

Medicinal chemistry and drug development

Pharmacological properties

Potential for biological activity modulation

Role of 4-[(4-bromo-3-fluorophenyl)oxy] group

Modulation of compound's biological activity

Research value

Valuable for further research in pharmaceutical drug development

Upstream product

• 121219-03-2 4-bromo-3-fluorophenol 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 348-57-2 2,4-difluorobromobenzene 

Downstream Products

• 684249-71-6 4-[(4-bromo-3-fluorophenyl)oxy]piperidine 

Relevant academic research and scientific papers

Regioselective SNAr reactions of substituted difluorobenzene derivatives: practical synthesis of fluoroaryl ethers and substituted resorcinols

In this Letter, we describe a practical and highly selective method for the preparation of fluoroaryl ethers and differentially substituted resorcinol derivatives. This synthetic strategy relies on a selective SNAr of substituted difluorobenzen

SUBSTITUTED PIPERAZINES, (1,4) DIASZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS

The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurodegenerative disorders including Alzheimer's disease.