684285-24-3

Upstream product

• 684284-38-6 7-(4-fluorobenzyl)-5-hydroxy-9-triisopropylsilanyloxypyrrolo[3,4-g]quinoline-6,8-dione 
• 13360-57-1 dimethylamino sulfonyl chloride 
• 684284-29-5 7-(4-fluoro-benzyl)-5,9-dihydroxy-pyrrolo[3,4-g]quinoline-6,8-dione 
• 13154-24-0 triisopropylsilyl chloride 

Downstream Products

• 684286-52-0 dimethylsulfamic acid 7-(4-fluoro-benzyl)-6-methylene-8-oxo-9-triisopropylsilanyloxy-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl ester 

Relevant academic research and scientific papers

Effect of substitution on novel tricyclic HIV-1 integrase inhibitors

A series of novel tricyclic inhibitors of HIV-1 integrase enzyme was prepared. The effect of substitution at C-6 of the 9-hydroxy-6,7-dihydropyrrolo[3,4-g]quinolin-8-one compounds was studied in vitro. Inhibitors with small side chains at C-6 were general

PHOSPHONATE ANALOGS OF HIV INTEGRASE INHIBITOR COMPOUNDS

Novel HIV integrase inhibitor compounds having at least one phosphonate group, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.

PRE-ORGANIZED TRICYCLIC INTEGRASE INHIBITOR COMPOUNDS

Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. Formula (I). Al and A2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl. Q is N, +NR, or CR4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.