68468-97-3Relevant academic research and scientific papers
Effective synthesis of 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines
Kulikov, Alexander S.,Epishina, Margarita A.,Fershtat, Leonid L.,Makhova, Nina N.
, p. 669 - 672 (2018)
[Figure not available: see fulltext.] A highly effective method for the preparation of 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines was developed on the basis of condensation reaction between aryl(hetaryl) α-bromo ketones and commercially available thiocarbohydrazide, followed by treatment of the obtained 2-hydrazinyl-6H-1,3,4-thiadiazine hydrobromides with ortho esters in the presence of trifluoroacetic acid under mild conditions.
