68471-55-6Relevant articles and documents
Direct Synthesis of Enamides via Electrophilic Activation of Amides
Berger, Martin,Kaiser, Daniel,Maulide, Nuno,Spie?, Philipp
, p. 10524 - 10529 (2021/07/28)
A novel, one-step N-dehydrogenation of amides to enamides is reported. This reaction employs the unlikely combination of LiHMDS and triflic anhydride, which serves as both the electrophilic activator and the oxidant, and is characterized by its simple setup and broad substrate scope. The synthetic utility of the formed enamides was readily demonstrated in a range of downstream transformations.
Visible-light, metal-free α-amino C(sp3)-H activation through 1,5-hydrogen migration: A concise method for the preparation of bis(indolyl)alkanes
Shaaban, Saad,Roller, Alexander,Maulide, Nuno
, p. 7643 - 7647 (2015/12/31)
A photoredox catalytic, metal-free method for C-H functionalization α to amines directly leads to the formation of bis(indolyl)alkane products in good to excellent yields. This transformation hinges on a smooth 1,5-hydrogen migration to an aryl radical in
Synthesis of polycyclic lactams and sultams by a cascade ring-closure metathesis/isomerization and subsequent radical cyclization
Bressy, Cyril,Menant, Christine,Piva, Olivier
, p. 577 - 582 (2007/10/03)
Starting from readily available substrates, a new one-pot procedure has been devised to prepare polycyclic lactams and sultams. 2-Pyrrolines obtained from N,N-bisallylamides by ring-closure metathesis and subsequent isomerization promoted by ruthenium hyd