685109-95-9

Upstream product

• 100-39-0 benzyl bromide 
• 685109-92-6 ethyl 3-O-tert-butyldimethylsilyl-1-thio-β-L-fucopyranoside 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 132799-10-1 ethyl 1-thio-α-L-fucopyranoside 

Downstream Products

• 685109-96-0 octyl 2,4-di-O-benzyl-3-O-tert-butyldimethylsilyl-β-L-fucopyranoside 
• 685109-98-2 octyl 2,4-di-O-benzyl-3-O-tert-butyldimethylsilyl-α-L-fucopyranosyl-(1->3)-2,4-di-O-benzyl-β-L-fucopyranoside 
• 685110-01-4 octyl 2,4-di-O-benzyl-3-O-tert-butyldimethylsilyl-α-L-fucopyranosyl-(1->3)-2,4-di-O-benzyl-α-L-fucopyranosyl-(1->3)-2,4-di-O-benzyl-β-L-fucopyranoside 
• 685110-00-3 octyl 2,4-di-O-benzyl-α-L-fucopyranosyl-(1->3)-2,4-di-O-benzyl-β-L-fucopyranoside 
• 685110-02-5 octyl 2,4-di-O-benzyl-α-L-fucopyranosyl-(1->3)-2,4-di-O-benzyl-α-L-fucopyranosyl-(1->3)-2,4-di-O-benzyl-β-L-fucopyranoside 
• 190248-98-7 ethyl 2,4-di-O-benzyl-1-thio-β-L-fucopyranoside 

Relevant academic research and scientific papers

A Modular Approach to a Library of Semi-Synthetic Fucosylated Chondroitin Sulfate Polysaccharides with Different Sulfation and Fucosylation Patterns

Fucosylated chondroitin sulfate (fCS)—a glycosaminoglycan (GAG) found in sea cucumbers—has recently attracted much attention owing to its biological properties. In particular, a low molecular mass fCS polysaccharide has very recently been suggested as a s

Synthesis and biological activities of octyl 2,3,4-tri-O-sulfo-α-L- fucopyranosyl-(1 → 3)-2,4-di-O-sulfo-α-L-fucopyranosyl-(1 → 3)-2,4-di-O-sulfo-α-L-fucopyranosyl-(1 → 3)-2,4-di-O-sulfo-β-L- fucopyranoside

An efficient method for the regioselective 3-O-silylation of β-thiofucopyranoside was disclosed. Based on this discovery, we described a high-yielding strategy for the synthesis of the natural core structure of L-fucan and its fully sulfated derivative. The bioassay suggested that octyl 2,3,4-tri-O-sulfo-α-L-fucopyranosyl-(1→3)-2,4-di-O-sulfo-α-L- fucopyranosyl-(1→3)-2,4-di-O-sulfo-α-L-fucopyranosyl-(1→3)-2, 4-di-O-sulfo-β-L-fucopyranoside presented better antitumor activities than that of the free tetramer based on Sarcoma 180 cells and Lewis lung carcinoma model studies.