685109-98-2

Upstream product

• 685109-96-0 octyl 2,4-di-O-benzyl-3-O-tert-butyldimethylsilyl-β-L-fucopyranoside 
• 685109-92-6 ethyl 3-O-tert-butyldimethylsilyl-1-thio-β-L-fucopyranoside 
• 132799-10-1 ethyl 1-thio-α-L-fucopyranoside 
• 100-39-0 benzyl bromide 
• 685109-95-9 ethyl 2,4-di-O-benzyl-3-O-tert-butyldimethylsilyl-1-thio-β-L-fucopyranoside 
• 685109-97-1 octyl 2,4-di-O-benzyl-β-L-fucopyranoside 

Downstream Products

• 685110-01-4 octyl 2,4-di-O-benzyl-3-O-tert-butyldimethylsilyl-α-L-fucopyranosyl-(1->3)-2,4-di-O-benzyl-α-L-fucopyranosyl-(1->3)-2,4-di-O-benzyl-β-L-fucopyranoside 
• 685110-02-5 octyl 2,4-di-O-benzyl-α-L-fucopyranosyl-(1->3)-2,4-di-O-benzyl-α-L-fucopyranosyl-(1->3)-2,4-di-O-benzyl-β-L-fucopyranoside 
• 685110-00-3 octyl 2,4-di-O-benzyl-α-L-fucopyranosyl-(1->3)-2,4-di-O-benzyl-β-L-fucopyranoside 

Relevant academic research and scientific papers

Synthesis and biological activities of octyl 2,3,4-tri-O-sulfo-α-L- fucopyranosyl-(1 → 3)-2,4-di-O-sulfo-α-L-fucopyranosyl-(1 → 3)-2,4-di-O-sulfo-α-L-fucopyranosyl-(1 → 3)-2,4-di-O-sulfo-β-L- fucopyranoside

An efficient method for the regioselective 3-O-silylation of β-thiofucopyranoside was disclosed. Based on this discovery, we described a high-yielding strategy for the synthesis of the natural core structure of L-fucan and its fully sulfated derivative. The bioassay suggested that octyl 2,3,4-tri-O-sulfo-α-L-fucopyranosyl-(1→3)-2,4-di-O-sulfo-α-L- fucopyranosyl-(1→3)-2,4-di-O-sulfo-α-L-fucopyranosyl-(1→3)-2, 4-di-O-sulfo-β-L-fucopyranoside presented better antitumor activities than that of the free tetramer based on Sarcoma 180 cells and Lewis lung carcinoma model studies.