685139-79-1

Usage

Uses

Used in Pharmaceutical Industry:
(S,RP)-PH-DIAPHOX is used as a chiral ligand in asymmetric catalysis for the synthesis of chiral pharmaceutical compounds. Its high selectivity and reactivity are crucial for producing enantiomerically pure drugs, which are essential for ensuring the desired therapeutic effects and minimizing potential side effects.
Used in Agrochemical Industry:
(S,RP)-PH-DIAPHOX is utilized as a chiral ligand in the asymmetric synthesis of agrochemicals. Its ability to facilitate the production of chiral pesticides and other agrochemicals with high selectivity helps in developing more effective and environmentally friendly products.
Used in Fine Chemicals Industry:
(S,RP)-PH-DIAPHOX is employed as a chiral ligand in the synthesis of fine chemicals, which are high-purity chemicals used in various applications such as fragrances, flavors, and specialty materials. Its role in asymmetric catalysis ensures the production of enantiomerically pure compounds, which are vital for the performance and quality of these fine chemicals.
Overall, (S,RP)-PH-DIAPHOX is a versatile and essential ligand in the field of asymmetric catalysis, contributing significantly to the development and production of chiral compounds across various industries.

Upstream product

• 685139-83-7 (S)-8-Benzyl-2,7-diphenyl-2,7,8-triaza-1-phospha-bicyclo[3.2.1]octane 
• 685139-78-0 (2R)-N²-benzyl-N¹,N⁴-diphenyl-butane-1,2,4-triamine 
• 98-88-4 benzoyl chloride 
• 62-53-3 aniline 
• 685139-82-6 (2R)-2-amino-N¹,N⁴-diphenyl-succinamide 
• 685139-77-9 (2R)-2-benzoylamino-N¹,N⁴-diphenyl-succinamide 
• 685139-81-5 benzyloxycarbonyl-L-aspartic acid dianilide 

Relevant academic research and scientific papers

Enantioselective construction of all-carbon quaternary stereocenters using palladium-catalyzed asymmetric allylic alkylation of γ-acetoxy-α, β-unsaturated carbonyl compounds

We have successfully demonstrated that γ-acetoxy-α,β- unsaturated carbonyl compounds are useful starting materials for Pd-catalyzed asymmetric allylic alkylation to construct all-carbon quaternary stereocenters. With the use of 2-5 mol % of Pd catalyst an

Development of a new class of chiral phosphorus ligands: P-chirogenic diaminophosphine oxides. A unique source of enantioselection in Pd-catalyzed asymmetric construction of quaternary carbons

We have recently developed a new class of chiral phosphorus ligands: P-chirogenic diaminophosphine oxides. These pentavalent phosphorus compounds have been successfully applied to Pd-catalyzed asymmetric construction of tertiary and quaternary carbons. The actual ligand structure was the trivalent phosphorus species 17, which was generated in situ by BSA-induced P(V) to P(III) transformation of 6, the preligand. Detailed mechanistic studies, including asymmetric amplification and initial rate kinetics, revealed that complex 18 [Pd-17 (1:2) complex] was the active catalyst. The important function of the nitrogen atom on the sidearm in the ligands was also clarified. The source of enantioselection in the construction of asymmetric quaternary carbons was the secondary ligand substrate interaction mediated by N-Zn coordination.

P-Chirogenic Diaminophosphine Oxide: A New Class of Chiral Phosphorus Ligands for Asymmetric Catalysis

We successfully synthesized a novel P-chirogenic diaminophosphine oxide 4, which was applied to catalytic enantioselective construction of quaternary carbon centers using Pd-catalyzed asymmetric allylic substitution with various β-keto esters (up to 99% yield, 94% ee). Preliminary mechanistic studies indicated that two molecules of 8 coordinate to the Pd metal in a monodentate fashion, resulting in the formation of Pd complex 9 (Pd:8 = 1:2), which functions as the active species. Copyright