685139-79-1

Basic information

• Product Name: (S,RP)-PH-DIAPHOX
• Synonyms: (S,RP)-PH-DIAPHOX
• CAS NO: 685139-79-1
• Molecular Formula: C₂₃H₂₆N₃OP
• Molecular Weight: 391.45
• Mol File: 685139-79-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: approximate 130℃
• Appearance: /
• CAS DataBase Reference: (S,RP)-PH-DIAPHOX(CAS DataBase Reference)
• NIST Chemistry Reference: (S,RP)-PH-DIAPHOX(685139-79-1)
• EPA Substance Registry System: (S,RP)-PH-DIAPHOX(685139-79-1)

Safety Data

• Hazardous Substances Data: 685139-79-1(Hazardous Substances Data)

Usage

General Description

(S,RP)-PH-DIAPHOX is a chiral ligand that is commonly used in asymmetric catalysis. It is a phosphine-based ligand that has been widely utilized in various organic reactions to facilitate the synthesis of chiral compounds. This ligand is known for its high reactivity and selectivity in promoting asymmetric transformations, making it a valuable tool for the development of enantioselective processes. Its unique structure and properties make it suitable for a wide range of synthetic applications, including the production of pharmaceuticals, agrochemicals, and fine chemicals. Overall, (S,RP)-PH-DIAPHOX plays a crucial role in advancing the field of asymmetric catalysis and enabling the efficient and selective synthesis of chiral molecules.

Upstream product

• 685139-81-5 benzyloxycarbonyl-L-aspartic acid dianilide 
• 685139-77-9 (2R)-2-benzoylamino-N¹,N⁴-diphenyl-succinamide 
• 685139-82-6 (2R)-2-amino-N¹,N⁴-diphenyl-succinamide 
• 62-53-3 aniline 
• 98-88-4 benzoyl chloride 
• 685139-78-0 (2R)-N²-benzyl-N¹,N⁴-diphenyl-butane-1,2,4-triamine 
• 685139-83-7 (S)-8-Benzyl-2,7-diphenyl-2,7,8-triaza-1-phospha-bicyclo[3.2.1]octane 

Relevant articles and documents

Enantioselective construction of all-carbon quaternary stereocenters using palladium-catalyzed asymmetric allylic alkylation of γ-acetoxy-α, β-unsaturated carbonyl compounds

We have successfully demonstrated that γ-acetoxy-α,β- unsaturated carbonyl compounds are useful starting materials for Pd-catalyzed asymmetric allylic alkylation to construct all-carbon quaternary stereocenters. With the use of 2-5 mol % of Pd catalyst an

P-Chirogenic Diaminophosphine Oxide: A New Class of Chiral Phosphorus Ligands for Asymmetric Catalysis

We successfully synthesized a novel P-chirogenic diaminophosphine oxide 4, which was applied to catalytic enantioselective construction of quaternary carbon centers using Pd-catalyzed asymmetric allylic substitution with various β-keto esters (up to 99% yield, 94% ee). Preliminary mechanistic studies indicated that two molecules of 8 coordinate to the Pd metal in a monodentate fashion, resulting in the formation of Pd complex 9 (Pd:8 = 1:2), which functions as the active species. Copyright