68538-00-1Relevant academic research and scientific papers
Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone
Markovic, Violeta,Eric, Slavica,Juranic, Zorica D.,Stanojkovic, Tatjana,Joksovic, Ljubinka,Rankovic, Branislav,Kosanic, Marijana,Joksovic, Milan D.
, p. 18 - 27 (2011/04/15)
A series of aminomethylidene derivatives obtained from 4-formyledaravone were synthesized and characterized by IR, NMR and elemental analysis. All the compounds were screened for their antitumor activity. The compound containing 5-phenylpyrazole moiety (3q) exhibited remarkable antitumor activity in in vitro assays, especially against human breast cancer MDA-MB-361 and MDA-MB-453 cell lines. The most important whole-molecule descriptors for antitumor activity on MDA-MB-453 cells belong to the group of quantum-chemical descriptors.
