685534-98-9

Upstream product

• 7073-42-9 N-(3-chloro-4-methoxyphenyl)acetamide 
• 79-10-7 acrylic acid 
• 685536-12-3 2-bromo-5-chloro-4-methoxy-phenylamine 
• 685535-00-6 (E)-3-(2-amino-4-chloro-5-methoxyphenyl)-acryclic acid ethyl ester 
• 868406-57-9 (E)-3-(2-amino-4-chloro-5-methoxyphenyl)-acrylic acid 
• 75-36-5 acetyl chloride 
• 5345-54-0 3-chloro-4-methoxyaniline 

Downstream Products

• 685534-97-8 N-(5-chloro-2-[(E)-3-[(2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazin-1-yl]-3-oxopropenyl]-4-methoxyphenyl)-acetamide 

Relevant academic research and scientific papers

Pd-catalyzed ortho-selective oxidative coupling of halogenated acetanilides with acrylates

Coupling of different halogenated acetanilides with acrylates using Pd-catalyzed ortho-selective C-H bond activation is reported. The yields of coupled products are low to high depending on the substrate. In general, arenes with electron-rich substituents like methoxy and methyl groups gave higher yields of the coupled products. The presence of the halogen substituent did not interfere with the activation process under these conditions.

COMPOUNDS AS CCRI ANTAGONISTS

A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein the symbols have meaning as defined, which are antagonists of CCR-1 and which find use pharmaceutically for treatment of diseases and conditions in which CCR-1 is implicated, e.g. inflammatory diseases.