685540-89-0Relevant academic research and scientific papers
Design, synthesis, and biological evaluations of novel quinolones as HIV-1 non-nucleoside reverse transcriptase inhibitors
Ellis, David,Kuhen, Kelli L.,Anaclerio, Beth,Wu, Baogen,Wolff, Karen,Yin, Hong,Bursulaya, Badry,Caldwell, Jeremy,Karanewsky, Donald,He, Yun
, p. 4246 - 4251 (2007/10/03)
A novel series of quinolones was discovered as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) using a structure-based approach. The lead quinolones exhibited single digit nanomolar potency in the HIV-1 replication assays. The preliminary S
