685565-09-7Relevant articles and documents
Bodilisant - A novel fluorescent, highly affine histamine H3 receptor ligand
Tomasch, Miriam,Schwed, J. Stephan,Paulke, Alexander,Stark, Holger
supporting information, p. 269 - 273 (2013/03/28)
A piperidine-based lead structure for the human histamine H3 receptor (hH3R) was coupled with the BODIPY fluorophore and resulted in a strong green fluorescent (quantum yield, 0.92) hH3R ligand with affinity in the nanomolar concentration range (Ki hH3R = 6.51 ± 3.31 nM), named Bodilisant. Screening for affinities at histamine and dopamine receptor subtypes showed high hH3R preference. Bodilisant was used for visualization of hH3R in hH3R overexpressing HEK-293 cells with fluorescence confocal laser scanning microscopy. In addition, in native human brain tissues, Bodilisant showed clear and displaceable images of labeled hH3R.
ARYLOXYALKYLAMINE DERIVATES AS H3 RECEPTOR LIGANDS
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Page 20, (2010/02/06)
The present invention relates to novel benzyloxy derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.