6859-11-6

Usage

General Description

1-Methyl-5,5-diphenylimidazolidine-2,4-dione, also known as midazolam, is a medication that belongs to the class of benzodiazepines. It is primarily used as a sedative, anxiolytic, and for the treatment of insomnia and anxiety disorders. It works by enhancing the activity of a neurotransmitter in the brain called gamma-aminobutyric acid (GABA), which helps to calm the nervous system. Midazolam is often administered orally, intravenously, or intramuscularly, and its effects can be felt within a few minutes. It is considered a fast-acting medication and is commonly used in medical settings such as hospitals and clinics for procedures requiring sedation or anesthesia. Like all medications, midazolam can have potential side effects and interactions with other drugs, so it should only be used under the supervision of a healthcare professional.

Upstream product

• 13280-16-5 N-(diphenylmethylene)methylamine 
• 22544-73-6 1-methyl-2-methylsulfanyl-5,5-diphenyl-1,5-dihydro-imidazol-4-one 
• 7000-52-4 1-methyl-4-methylsulfanyl-5,5-diphenyl-1,5-dihydro-imidazol-2-one 
• 57-41-0 phenythoin 
• 74-88-4 methyl iodide 
• 134-81-6 benzil 
• 598-50-5 N-Methylurea 
• 2032-17-9 2,5-bis-methylsulfanyl-4,4-diphenyl-4H-imidazole 
• 2032-13-5 Thiophenytoin 
• 856-85-9 3-(morpholinomethyl)-5,5-diphenylimidazolidine-2,4-dione 
• 3718-53-4 4-methylsulfanyl-5,5-diphenyl-1,5-dihydro-imidazole-2-thione 
• 2032-16-8 4-methylsulfanyl-5,5-diphenyl-1,5-dihydro-imidazol-2-one 
• 22544-70-3 2-(methylthio)-4,4-diphenyl-5-imidazolinone 

Downstream Products

• 6826-03-5 1-methyl-5,5-diphenyl-imidazolidine-2,4-dithione 
• 16116-39-5 1,4-S-Dimethyl-5,5-diphenyl-dithiohydantoin 
• 21083-49-8 1-methyl-5,5-diphenyl-2-thioxo-imidazolidin-4-one 

Relevant academic research and scientific papers

Direct N1-selective alkylation of hydantoins using potassium bases

Hydantoins, including the antiepileptic drug phenytoin, contain an amide nitrogen and an imide nitrogen, both of which can be alkylated. However, due to the higher acidity of its proton, N3 can be more easily alkylated than N1 under

Facile access to polymer supported zinc–salen complex: highly efficient heterogeneous catalyst for synthesizing hydantoins, thiohydantoins and Schiff bases in aqueous medium

The synthesis of polymer supported zinc–salen complex (PS-Zn–salen) is described. The mononuclear zinc(II)–salen complex was characterized by Fourier-transform NMR spectroscopy, energy-dispersive X-ray spectroscopy, Fourier transform infrared spectrophotometry (FT-IR), thermogravimetric analysis, scanning electron microscopy, surface area and pore size distribution by Brunauer–Emmett–Teller. The synthesized PS-Zn–salen complex used as a recyclable heterogeneous catalyst for the efficient synthesis of hydantoins, thiohydantoins and Schiff bases in an aqueous medium. The isolated yields of hydantoins, thiohydantoins and Schiff bases achieved up to 89, 95 and 94%, respectively. In spite of conventional heterogeneous catalysts, current PS-Zn–salen complex shows thermal stability up to 280?°C. Moreover, the catalyst could be recovered easily by simple filtration and reused for next run with slightly declining its activity up to six successive runs. The FT-IR spectrum of recycle catalyst after 6th run confirmed that the catalyst was stable during the course of a reaction. The leaching of metal from the PS-Zn–salen is negligible, which was confirmed by AAS and hot filtration test.