856-85-9Relevant academic research and scientific papers
Microwave-assisted synthesis of some novel and potent antibacterial and antifungal compounds with biological screening
Bapna, Mayank,Parashar, Bharat,Sharma, Vinod K.,Chouhan, Lalit S.
, p. 1098 - 1106 (2012/08/07)
Hydantoins have widely been used as antiarrythmic, anticonvulsant and antitumor agents but recent research has shown a different and novel cytotoxic activity of hydantoins and its derivatives, i.e. anti HIV, antibacterial and antifungal. The following research article deals with the synthesis of hydantoins and their derivatives by Mannich reaction viz., 3-(substituted)-5,5- diphenylimidazolidine-2,4-dione and 1-(substituted)-3,5,5- triphenylimidazolidine-2,4-dione. The synthesised compounds are novel and some of the compounds showed good antibacterial and antifungal activity equivalent to the standards used. All synthetic procedures were carried out in a microwave and not by conventional methods, which led to speedy process and high yield for the same. Springer Science+Business Media, LLC 2011.
Photochemical Cyclisation of 3-N-(Dialkylaminomethyl)imidazole-2,4-diones to 1,3,7-Triazabicyclooctanes
Coyle, John D.,Bryant, Laurence R.B.
, p. 531 - 534 (2007/10/02)
Ultraviolet irradiation of N-3 Mannich bases derived from hydantoin or from 5,5-disubstituted hydantoins (imidazole-2,4-diones), provides an efficient route to 1,3,7-triazabicyclooctane derivatives by photocyclisation to the C-4 carbonyl group.
