6859-53-6

Basic information

• Product Name: 1-chloro-3-(2-methoxyphenyl)-2-propanol
• Synonyms: 1-chloro-3-(2-methoxyphenyl)-2-propanol
• CAS NO: 6859-53-6
• Molecular Weight: 200.665
• Mol File: 6859-53-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-chloro-3-(2-methoxyphenyl)-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-3-(2-methoxyphenyl)-2-propanol(6859-53-6)
• EPA Substance Registry System: 1-chloro-3-(2-methoxyphenyl)-2-propanol(6859-53-6)

Safety Data

• Hazardous Substances Data: 6859-53-6(Hazardous Substances Data)

Upstream product

• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 106-89-8 epichlorohydrin 
• 100-66-3 methoxybenzene 
• 3698-28-0 2-allylanisole 

Downstream Products

• 6728-84-3 4-(o-Methoxy-phenyl)-3-hydroxy-buttersaeureethylester 
• 20808-38-2 4-(o-Methoxy-phenyl)-3-hydroxy-buttersaeureamid 
• 6732-26-9 4-(o-Methoxy-phenyl)-3-hydroxy-buttersaeure 
• 6732-49-6 3-Hydroxy-4-(2-methoxy-phenyl)-butyronitrile 

Relevant articles and documents

Regioselective ring-opening of epoxides with ortho-lithioanisoles catalyzed by BF3·OEt2

It is presented that a number of o-2-hydroxyalkylanisoles could be efficiently synthesized through the regioselective ring-opening reaction of epoxides with o-lithioanisoles in the presence of BF3·OEt 2 Lewis-acid catalyst. Sterically demanding o-lithioanisoles had to be generated by exploiting the combination of nBuLi and a catalytic amount of TMEDA (0.20 equiv) in Et2O as the lithiator whereas 'normal' anisole could be lithiated at ortho-position by treatment with nBuLi in THF as usual. Surprisingly, the availability of THF and a catalytic amount of TMEDA (0.20 equiv) in the reaction mixture was found to enhance the reaction yields dramatically. A complex aggregate formation by the co-operative ligation of THF and TMEDA to ortho-lithioanisole(s) was proposed to rationalize the high reactivity achieved in the ring-opening reaction of epoxides.