6859-53-6Relevant academic research and scientific papers
Regioselective ring-opening of epoxides with ortho-lithioanisoles catalyzed by BF3·OEt2
Ertürk, Erkan,Tezeren, Mustafa A.,Atalar, Taner,Tilki, Tahir
experimental part, p. 6463 - 6471 (2012/08/27)
It is presented that a number of o-2-hydroxyalkylanisoles could be efficiently synthesized through the regioselective ring-opening reaction of epoxides with o-lithioanisoles in the presence of BF3·OEt 2 Lewis-acid catalyst. Sterically demanding o-lithioanisoles had to be generated by exploiting the combination of nBuLi and a catalytic amount of TMEDA (0.20 equiv) in Et2O as the lithiator whereas 'normal' anisole could be lithiated at ortho-position by treatment with nBuLi in THF as usual. Surprisingly, the availability of THF and a catalytic amount of TMEDA (0.20 equiv) in the reaction mixture was found to enhance the reaction yields dramatically. A complex aggregate formation by the co-operative ligation of THF and TMEDA to ortho-lithioanisole(s) was proposed to rationalize the high reactivity achieved in the ring-opening reaction of epoxides.
Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof
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Page/Page column 30, (2008/06/13)
The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory- and immune-associ
