686-11-3

Basic information

• Product Name: Acetamide, N,N-diethyl-2,2-difluoro-
• CAS NO: 686-11-3
• Molecular Formula: C6H11F2NO
• Molecular Weight: 151.156
• Mol File: 686-11-3.mol

Chemical Properties

• CAS DataBase Reference: Acetamide, N,N-diethyl-2,2-difluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N,N-diethyl-2,2-difluoro-(686-11-3)
• EPA Substance Registry System: Acetamide, N,N-diethyl-2,2-difluoro-(686-11-3)

Safety Data

• Hazardous Substances Data: 686-11-3(Hazardous Substances Data)

Upstream product

• 67406-60-4 2,2-dichloro-1,1-difluoroethyldiethylamine 
• 680-63-7 N-(1,1,2,2-tetrafluoroethyl)diethylamine 
• 407-25-0 trifluoroacetic anhydride 
• 857899-86-6 (1-hydrohexafluoroisobutenyloxy)trimethylsilane 

Downstream Products

• 114829-07-1 ω,ω-Difluoro-4-methoxyacetophenone 
• 454-31-9 ethyl difluoroacetate 
• 352-24-9 ethyl 4,4-difluoro-3-oxobutyrate 
• 704-36-9 2,2-difluoro-1-(4-methylphenyl)ethan-1-one 
• 703-42-4 2,2-difluoro-1-(o-tolyl)ethan-1-one 
• 715-80-0 2,2-difluoro-1-(naphthalen-1-yl)ethan-1-one 
• 395-01-7 2,2-difluoro-1-phenylethanone 
• 381-73-7 Difluoroacetic acid 

Relevant articles and documents

Reaction of 1-hydrohexafluoroisobutenyloxytrimethylsilane with fluoride ion sources. 2,2,2′,2′-Tetrakis(trifluoromethyl)divinyl ether

The reaction of 1-hydrohexafluoroisobutenyloxytrimethylsilane (2a) with cesium fluoride in diglyme leads to elimination of trimethylfluorosilane to form the 1-hydrohexafluoroisobutenolate anion (3), which is silylated with trialkylchlorosilanes at the oxygen atom. In the presence of bis(trifluoromethyl)ketene N,N,O-trimethylaminoacetal or N-(α,α- difluoroalkyl)-dialkylamines, silane 2a is transformed into 2,2,2′, 2′-tetrakis(trifluoromethyl)divinyl ether. The reaction of trifluoroacetic anhydride with N-(1,1,2,2-tetrafluoroethyl)diethylamine affords trifluoroacetyl fluoride in quantitative yield.

TRANSFORMATION OF CHLOROFLUOROETHYLDIETHYLAMINES TO N,N-DIETHYLDIFLUOROACETAMIDE

Hydrolysis of 2-chloro-1,1,2-trifluoroethyldiethylamine (I) and 2,2-dichloro-1,1-difluoroethyldiethylamine (II) in the presence of triethylamine afforded N,N-diethylchlorofluoroacetamide (VII) and N,N-diethyldichloroacetamide (VIII), respectively.Triethylamine hydrofluoride, arising in the reaction, was used for fluorination and transformation of the amides VII and VIII to N,N-diethyldifluoroacetamide (VI).The C-Cl bond of the CHClF group in VII proved to be more reactive in nucleophilic substitution with fluoride ion than the corresponding bond in the CHCl2 group of VIII.