6861-51-4Relevant academic research and scientific papers
An Improved Procedure for the Preparation of Acetals from Diaryl Ketones
Thurkauf, Andrew,Jacobson, Arthur E.,Rice, Kenner C.
, p. 233 - 234 (2007/10/02)
Acetals of diaryl ketones with nitro, halo and methoxy substituents are easily prepared in high yield by treatment with an alcohol and the corresponding trialkyl ortoformate in the presence of catalytic amount of trifluoromethanesulfonic acid.
Dehalogenation of 1-Halogenothienyl-di- and -tetra-hydroisoquinolines by Sodium Methoxide in Dimethyl Sulphoxide
Barker, John M.,Huddleston, Patrick R.,Clephane, Janette,Wood, Michael L.,Holmes, David
, p. 275 - 282 (2007/10/02)
On treatment with sodium methoxide-dimethyl sulphoxide (NaOMe-DMSO) 1-(5-halogeno-2-thienyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolines suffer loss of halogen and are converted into the related 1-hydroxytetrahydroisoquinolines.The reaction fails with comparable 1-bromophenyl- and 1-(halogeno-3-thienyl)tetrahydroisoquinolines.A similar transformation takes place with (5-halogeno-2-thienyl)phenylmethoxymethanes, leading to the dimethyl acetal of the 5-dehalogenated-2-thienyl phenyl ketone. α-Halogenated-2 and 3-thienyl-3,4-dihydroisoquinolines undergo dehalogenation-aromatisation with NaOMe-DMSO.Mechanisms for these conversions are proposed.
