36404-90-7

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-3-formylpyridine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its presence in the molecular structure can influence the biological activity and pharmacokinetic properties of the resulting drugs, making it a valuable component in drug discovery and development.
Used in Organic Synthesis:
In the field of organic synthesis, 2-Fluoro-3-formylpyridine is utilized as a building block for the creation of complex organic molecules. Its reactivity and functional groups allow for a range of chemical reactions, such as nucleophilic substitution, to produce a variety of derivatives with different properties and applications.
Used in the Synthesis of Naphthyridines:
2-Fluoro-3-formylpyridine is used as a precursor in the synthesis of naphthyridines, a class of nitrogen-containing heterocyclic compounds with potential applications in medicinal chemistry. The attachment of isoxazolinones through a displacement of the fluoride group, followed by hydrogenolysis and cyclization, leads to the formation of naphthyridine derivatives with potential biological activities.

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 119899-26-2 2-fluoronicotinic acid chloride 
• 393-55-5 2-fluoronicotinic acid 
• 2369-18-8 2-fluoro-3-methylpyridine 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 766-11-0 5-bromo-2-fluoropyridine 
• 109-94-4 formic acid ethyl ester 
• 131747-55-2 2-fluoro-3-(hydroxymethyl)pyridine 
• 2591-86-8 N-Formylpiperidine 
• 372-48-5 2-fluoropyridine 

Downstream Products

• 1259948-69-0 2-fluoro-3-{2-fluoro-2-[4-(trifluoromethyl)phenyl]vinyl}pyridine 
• 465514-09-4 2-morpholinonicotinaldehyde 
• 86618-09-9 ethyl 2-(5H-chromeno[2,3-b]pyridin-7-yl)propanoate 
• 52549-17-4 2-(5h-[1]benzopyrano[2,3-b]pyridin-7-yl)propionic acid 
• 4767-80-0 isothiazolo<4,5-b>pyridine 
• 1161864-92-1 2-(benzenesulfonyl)pyridine-3-carboxaldehyde 
• 108338-05-2 2-Fluoro-2',6'-dimethyl-1',4'-dihydro-[3,4']bipyridinyl-3',5'-dicarboxylic acid 5'-[2-(benzyl-methyl-amino)-ethyl] ester 3'-methyl ester 

Relevant academic research and scientific papers

Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning

Fluoroheterocyclic aldoximes were screened as therapeutic agents for the treatment of anticholinesterase poisoning. 2-Fluoropyridine-3- and -6-aldoxime, and 3-fluoropyridine-2- and -4-aldoxime, were synthesised. Attempts to obtain 3,5,6-trifluoropyridine-2,4-bis(aldoxime) and -2-aldoxime, however, proved unsuccessful. Pentafluorobenzaldoxime was prepared by oximation of pentafluorobenzaldehyde. Acid dissociation constants (pKa) and second-order rate constants (kox-) of the fluorinated pyridinealdoximes towards sarin were measured. 2,3,5,6-Tetrafluoropyridine-4- aldoxime had the best profile: its kox- approached that of the therapeutic oxime P2S (310 vs. 120 l mol-1 min-1), but its higher pKa (9.1 vs. 7.8) fell short of the target figure of 8 required for reactivation of inhibited acetylcholinesterase in vivo. N-alkylation of the fluorinated pyridine-aldoximes may reduce their pK a nearer to 8 and enhance their therapeutic potential. Crown Copyright

TETRACYCLIC INHIBITORS OF JANUS KINASES

The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

USING ALKYLMETAL REAGENTS FOR DIRECTED METALATION OF AZAAROMATICS

Substituted alkylmetal reagents such as (trimethylsilylmethyl)lithium are reacted with azaaromatic compounds and/or nitrogen heterocycle compounds to produce functionalized azaaromatic compounds and functionalized nitrogen heterocycle compounds.

UROKINASE INHIBITORS

Disclosed are benzothiophene and thienothiophene derivatives useful for inhibiting urokinase activity.

Le phenyl-lithium: nouvel agent de metallation du cycle pyridinique

Nucleophilic addition was the sole reaction of phenyl-lithium with a pyridinic ring; now the novel catalysed metallation, with phenyl-lithium, of many substituted pyridine compounds giving various derivatives in high yields with many different reagents, has been achieved.

Migration du lithium en serie pyridinique: double catalyse et reformage. Acces aux derives de la bromo-2 lithio-3 pyridine et des bromo-4 halogeno-2 lithio-3 pyridines

The lithium of an organolithium-pyridinic derivative can be moved from one position to an another by an intermolecular reaction.Two new reactions are possible for pyridinic organic synthesis: the isomerisation of any lithio derivative to a more stable one, and a reaction that transforms a mixture of various bromo-lithio derivatives into a single one.The processes involved and the experimental tools used are described in terms of the 2-bromo-3-lithio- and 4-bromo-2-halogeno-3-lithiopyridines derivatives synthesis.