686266-20-6

Upstream product

• 36239-09-5 ethyl chlorocarbonylacetate 
• 686266-19-3 ethyl 2-[(benzyloxy)amino]nicotinate 

Downstream Products

• 1003931-48-3 1-(benzyloxy)-4-hydroxy-1,8-naphthyridin-2(1H)-one 
• 1003934-25-5 1-(benzyloxy)-2-oxo-1,2-dihydro-1,8-naphthyridine-4-carboxylic acid 
• 1003934-14-2 1-(benzyloxy)-4-(1H-pyrazol-4-yl)-1,8-naphthyridin-2(1H)-one 
• 1003933-22-9 3-[1-(benzyloxy)-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]benzaldehyde 
• 1003933-05-8 4-anilino-1-(benzyloxy)-1,8-naphthyridin-2(1H)-one 
• 1003933-08-1 4-[benzyl(methyl)amino]-1-(benzyloxy)-1,8-naphthyridin-2(1H)-one 
• 1003933-90-1 1-(benzyloxy)-4-(3-hydroxyphenyl)-1,8-naphthyridin-2(1H)-one 
• 1003933-02-5 (1-benzyloxy-2-oxo-1,8-naphthyridin-4-yl) trifluoromethanesulfonate 
• 1003933-82-1 1-(benzyloxy)-4-(3-bromobenzyl)-1,8-naphthyridin-2(1H)-one 
• 1003934-21-1 1-(benzyloxy)-4-(3,4-dihydronaphthalen-2-yl)-1,8-naphthyridin-2(1H)-one 
• 1003933-30-9 1-(benzyloxy)-4-hydroxy-2-oxo-N-phenyl-1,2-dihydro-1,8-naphthyridine-3-carboxamide 

Relevant academic research and scientific papers

1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS

1-Hydroxy naphthyridine compounds (e.g., 1-hydroxy naphthyridin-2(1H)-one compounds of Formula I are inhibitors of HIV integrase and/or HIV RNase H and inhibitors of HIV replication: (I) wherein X and R1-R6 are as defined herein. The compounds are useful in the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other anti-HIV agents such as HIV antivirals, immunomodulators, antibiotics and vaccines.

Inhibitors of HCV NS5B polymerase: Synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines

N-1-Alkylamino and N-1-alkyloxy-4-hydroxyquinolon-3-yl benzothiadiazines were synthesized and evaluated as inhibitors of genotype 1 HCV polymerase. The N-1-alkyloxy derivatives were not potent inhibitors, however N-1-alkylamino derivatives displayed compa

Anti-infective agents

Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.

Anti-infective agents

The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HC