68641-85-0 Usage
Uses
Used in Pharmaceutical Industry:
rac-Naproxen 2-Propyl Ester is used as an impurity in the synthesis and production of Naproxen (N377520), a non-steroidal anti-inflammatory agent. It serves as a reference compound for quality control and analytical purposes in the pharmaceutical industry, ensuring the purity and efficacy of the final drug product.
As an ester derivative of Naproxen, rac-Naproxen 2-Propyl Ester may also be investigated for its potential applications in drug delivery systems. Esterification can improve the drug's lipophilicity, which may enhance its absorption through biological membranes and potentially increase its bioavailability. This could be particularly useful in the development of novel drug formulations with improved pharmacokinetic properties.
Additionally, rac-Naproxen 2-Propyl Ester may be studied for its potential as a prodrug. Prodrugs are biologically inactive compounds that are converted into active drugs within the body through metabolic processes. If found to have favorable properties, rac-Naproxen 2-Propyl Ester could be developed as a prodrug to improve the delivery and efficacy of Naproxen in treating inflammation and pain.
Check Digit Verification of cas no
The CAS Registry Mumber 68641-85-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,6,4 and 1 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 68641-85:
(7*6)+(6*8)+(5*6)+(4*4)+(3*1)+(2*8)+(1*5)=160
160 % 10 = 0
So 68641-85-0 is a valid CAS Registry Number.
68641-85-0Relevant academic research and scientific papers
Mu?oz-Mu?iz, Omar,Juaristi, Eusebio
, p. 2023 - 2026 (2003)
Racemic methyl, iso-propyl, and tert-butyl ester derivatives of naproxen were treated with achiral LDA base to give the corresponding prochiral enolates 2-Li, 3-Li, and 4-Li. Protonation of these enolates with novel chiral proton sources (S)-10 and (S,S)-11, containing the α-phenylethylamino group, proceeded in a highly enantioselective manner. Saponification of enantioenriched ester derivatives 2-4 afforded naproxen, (S)-1, with no loss of enantiopurity.
Catalytic enantioselective construction of all-carbon quaternary stereocenters: Synthetic and mechanistic studies of the C-acylation of silyl ketene acetals
Mermerian, Ara H.,Fu, Gregory C.
, p. 5604 - 5607 (2007/10/03)
With the aid of an appropriate chiral catalyst, acyclic silyl ketene acetals react with anhydrides to furnish 1,3-dicarbonyl compounds that bear all-carbon quaternary stereocenters in good ee and yield. Mechanistic studies provide strong support for a catalytic cycle that involves activation of both the electrophile (anhydride → acylpyridinium) and the nucleophile (silyl ketene acetal → enolate).
