68641-85-0

Basic information

• Product Name: rac-Naproxen 2-Propyl Ester
• Synonyms: rac-Naproxen 2-Propyl Ester;Isopropyl-2-(6-Methoxy-2-naphthyl) propionate;isopropyl 2-(2-methoxynaphthalen-6-yl)propanoate;KABDXMXJNHRMMO-UHFFFAOYSA-N
• CAS NO: 68641-85-0
• Molecular Formula: C₁₇H₂₀O₃
• Molecular Weight: 272.3389
• Product Categories: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 68641-85-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 381.2±17.0 °C(Predicted)
• Appearance: /
• Density: 1.085±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly)
• CAS DataBase Reference: rac-Naproxen 2-Propyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: rac-Naproxen 2-Propyl Ester(68641-85-0)
• EPA Substance Registry System: rac-Naproxen 2-Propyl Ester(68641-85-0)

Safety Data

• Hazardous Substances Data: 68641-85-0(Hazardous Substances Data)

Usage

Uses

rac-Naproxen 2-Propyl Ester is an impurity of Naproxen (N377520) an non-steroidal antiinflammatory agent.

Upstream product

• 23981-80-8 naproxen 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 22204-53-1 (2S)-2-(6-methoxy(2-naphthyl))propanoic acid 

Relevant articles and documents

Enantioselective protonation of prochiral enolates in the asymmetric synthesis of (S)-naproxen

Racemic methyl, iso-propyl, and tert-butyl ester derivatives of naproxen were treated with achiral LDA base to give the corresponding prochiral enolates 2-Li, 3-Li, and 4-Li. Protonation of these enolates with novel chiral proton sources (S)-10 and (S,S)-11, containing the α-phenylethylamino group, proceeded in a highly enantioselective manner. Saponification of enantioenriched ester derivatives 2-4 afforded naproxen, (S)-1, with no loss of enantiopurity.