68654-52-4

Basic information

• Product Name: 2-PIPERIDINOPYRIDINE 97
• Synonyms: 2-PIPERIDINOPYRIDINE 97;2-piperidin-1-ylpyridine
• CAS NO: 68654-52-4
• Molecular Formula: C₁₀H₁₄N₂
• Molecular Weight: 162.235
• Product Categories: Heterocyclic Compounds;C9 to C46;Heterocyclic Building Blocks;Pyridines
• Mol File: 68654-52-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 135-138 °C20 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.044 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0036mmHg at 25°C
• Refractive Index: 1.547
• PKA: 8.67±0.19(Predicted)
• CAS DataBase Reference: 2-PIPERIDINOPYRIDINE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PIPERIDINOPYRIDINE 97(68654-52-4)
• EPA Substance Registry System: 2-PIPERIDINOPYRIDINE 97(68654-52-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 68654-52-4(Hazardous Substances Data)

Usage

General Description

2-Piperidinopyridine 97 is a chemical compound with the molecular formula C10H12N2. It is a heterocyclic compound that consists of a piperidine ring fused to a pyridine ring, and it is commonly used as a building block in organic synthesis. This chemical has a purity of 97%, and it is often used as a reagent in pharmaceutical and agrochemical research. Additionally, 2-piperidinopyridine 97 has also been utilized in the development of various biologically active compounds and as a precursor to other important organic molecules. Its versatile nature makes it a valuable tool in the synthesis of complex chemical structures.

InChI:InChI=1/C10H14N2/c1-4-8-12(9-5-1)10-6-2-3-7-11-10/h2-3,6-7H,1,4-5,8-9H2

Upstream product

• 372-48-5 2-fluoropyridine 
• 110-89-4 piperidine 
• 109-04-6 2-bromo-pyridine 
• 109-09-1 2-chloropyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 127-19-5 N,N-dimethyl acetamide 

Downstream Products

• 92-52-4 biphenyl 
• 1449484-99-4 2-(2-(2-isopropylphenyl)piperidin-1-yl)pyridine 
• 1449484-56-3 C₂₆H₃₀N₂ 
• 1449484-97-2 2-(2,5-dimethylphenyl)-1-(pyridin-2-yl)piperidine 
• 1449484-95-0 2-(2-methylphenyl)-1-(pyridin-2-yl)piperidine 
• 1449484-55-2 cis-2,6-bis(2-methylphenyl)-1-(pyridin-2-yl)piperidine 
• 1449484-93-8 3-(1-(pyridin-2-yl)piperidin-2-yl)aniline 
• 1449484-54-1 cis-3,3'-(1-(pyridin-2-yl)piperidine-2,6-diyl)dianiline 
• 1449484-91-6 2-(2-(4-methoxyphenyl)piperidin-1-yl)pyridine 
• 1449484-53-0 cis-2-(2,6-bis(4-methoxyphenyl)piperidin-1-yl)pyridine 
• 1449484-89-2 2-(2-(3-methoxyphenyl)piperidin-1-yl)pyridine 
• 1449484-52-9 cis-2-(2,6-bis(3-methoxyphenyl)piperidin-1-yl)pyridine 
• 1449484-87-0 2-(2-(2-methoxyphenyl)piperidin-1-yl)pyridine 
• 1449484-86-9 2-(4-cyanophenyl)-1-(pyridin-2-yl)piperidine 

Relevant articles and documents

Magnesium-mediated arylation of amines via C-F bond activation of fluoroarenes

A series of new Mg(ii) amides featuring a bulky β-diketiminate backstop ligand, has been synthesised. These complexes are demonstrated to be excellent sources of nucleophilic amides that can participate in rapid C-F activation of several fluoroarenes at room temperature or using microwave assistance, leading to the installment of synthetically important C-N bonds via nucleophilic substitution.

Direct uncatalyzed amination of 2-chloropyridine using a flow reactor

Chloropyridines are efficiently converted into 2-amino-pyridines by uncatalyzed nucleophilic aromatic substitution (SNAr) in NMP using a continuous-flow reactor. A variety of secondary amines undergo SNAr with both electron-rich and electron-deficient 2-chloropyridines to afford 2-aminopyridines in good to excellent yield. The flow reactor, which provides a short reaction time and high temperatures up to 300°C, can overcome the activation barrier for reactions with unactivated substrates. Short reaction times result in fewer side products and can afford milligram to multigram quantities of product using continuous flow. Georg Thieme Verlag Stuttgart.