68662-68-0Relevant academic research and scientific papers
Three-component synthesis of highly functionalized aziridines containing a peptide side chain and their one-step transformation into β-functionalized α-ketoamides
Huck, Lena,González, Juan F.,De La Cuesta, Elena,Menéndez, J. Carlos
supporting information, p. 1772 - 1777 (2016/10/05)
A sequential three-component process is described, starting from 3-arylmethylene-2,5-piperazinediones and involving a one-pot sequence of reactions achieving regioselective opening of the 2,5-diketopiperazine ring and diastereoselective generation of an aziridine ring. This method allows the preparation of N-unprotected, trisubstituted aziridines bearing a peptide side chain under mild conditions. Their transformation into β-trifluoroacetamido-α-ketoamide and α,β-diketoamide frameworks was also achieved in a single step.
α,β-Unsaturated Carboxylic Acid Derivatives. Part 18. Syntheses of Geometric Isomers of 3,6-Dibenzylidene- and 3-p-Anisylidene-6-benzylidene-2,5-piperazinediones
Shin, Chung-gi,Hayakawa, Masato,Kato, Haruo,Mikami, Kazutoshi,Yoshimura, Juji
, p. 419 - 421 (2007/10/02)
Naturally occuring 3,6-dibenzylidene- and 3-p-anisylidene-6-benzylidene-2,5-piperazinediones and their geometric isomers were synthesized by the condensation of 1-acetyl or 1,4-diacetyl derivative of (E)- and (Z)-benzylidene- or p-anisylidene-2,5-piperazinediones with an appropriate aldehyde.The configuration of these compounds were assigned on the basis of the spectroscopic analyses, and those of natural products were determined to be (3Z,6Z).
