68674-48-6Relevant academic research and scientific papers
Zn(OTf)2-catalyzed cyclization of proparyl alcohols with anilines, phenols, and amides for synthesis of indoles, benzofurans, and oxazoles through different annulation mechanisms
Kumar, Manyam Praveen,Liu, Rai-Shung
, p. 4951 - 4955 (2007/10/03)
Zn(OTf)2 (10 mol %) catalyzed the cyclization of propargyl alcohols with PhXH (X = O, NH) in hot toluene (100 °C) without additive and gave indole and benzofuran products with different structures. In such transformations, α-carbonyl intermedia
An annulative approach to highly substituted indoles: Unusual effect of phenolic additives on the success of the arylation of ketone enolates
Rutherford, Jennifer L.,Rainka, Matthew P.,Buchwald, Stephen L.
, p. 15168 - 15169 (2007/10/03)
A novel palladium-catalyzed arylation of ketone enolates with o-nitrohaloarenes was achieved through the addition of phenol additives. The mild reaction conditions employed allowed for the inclusion of a wide variety of functional groups in both substrates to be tolerated. The products of this reaction were then readily reductively cyclized to give highly substituted indoles in moderate to excellent overall yields. Copyright
