68707-63-1Relevant academic research and scientific papers
C-H Oxidation/Michael Addition/Cyclization Cascade for Enantioselective Synthesis of Functionalized 2-Amino-4H-chromenes
Wu, Bo,Gao, Xiang,Yan, Zhong,Chen, Mu-Wang,Zhou, Yong-Gui
, p. 6134 - 6137 (2016/01/09)
A streamlined method for the enantioselective synthesis of 2-amino-4H-chromenes from readily available 2-alkyl-substituted phenols and active methylene compounds bearing a cyano group with up to 97% ee is presented. This reaction is a cascade procedure including manganese dioxide mediated C-H oxidation for the generation of o-quinone methides and bifunctional squaramide-catalyzed Michael addition/cyclization.
Thermochromic Furofuranes, II. - Synthesis and Thermolytic Behavior of Spiroquinole Ethers with Naphthalene Nucleus
Laatsch, Hartmut,Ernst, Bernd Peter
, p. 1245 - 1250 (2007/10/02)
To obtain further insight into the new photochromic system 2/3, various 3,4-disubstituted spiroquinole ethers 7 have been synthesized by oxidation of 2-alkyl-4-methoxy-1-naphtholes 5 via the corresponding quinone methides 6.Unlike 7a, the ethers 7b-d did
2-Substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity
Batt,Maynard,Petraitis,Shaw,Galbraith,Harris
, p. 360 - 370 (2007/10/02)
The synthesis, biological evaluation, and structure-activity relationships of a series of 1-naphthols bearing carbon substituents at the 2-position are described. These compounds are potent inhibitors of the 5-lipoxygenase from RBL-1 cells and also inhibi
