68709-94-4Relevant articles and documents
An effective and safe enkephalin analog for antinociception
Durgarao Viswanadham,B?ttger, Roland,Hohenwarter, Lukas,Nguyen, Anne,Rouhollahi, Elham,Smith, Alexander,Tsai, Yi-Hsuan,Chang, Yuan-Yu,Ortiz, Christopher Llynard,Yang, Lee-Wei,Jimenez, Liliana,Li, Siyuan,Hur, Chan,Li, Shyh-Dar
, (2021/07/10)
Opioids account for 69,000 overdose deaths per annum worldwide and cause serious side effects. Safer analgesics are urgently needed. The endogenous opioid peptide Leu-Enkephalin (Leu-ENK) is ineffective when introduced peripherally due to poor stability a
Silver-catalyzed late-stage fluorination
Tang, Pingping,Furuya, Takeru,Ritter, Tobias
supporting information; experimental part, p. 12150 - 12154 (2010/10/04)
Carbon-fluorine bond formation by transition metal catalysis is difficult, and only a few methods for the synthesis of aryl fluorides have been developed. All reported transition-metal-catalyzed fluorination reactions for the synthesis of functionalized arenes are based on palladium. Here we present silver catalysis for carbon-fluorine bond formation. Our report is the first example of the use of the transition metal silver to form carbon-heteroatom bonds by cross-coupling catalysis. The functional group tolerance and substrate scope presented here have not been demonstrated for any other fluorination reaction to date.
Amino acids and peptides, 50 - Activated N,N-dimethylamino acids. - Synthesis of enkephalines containing N,N-dimethyltyrosine
Schmidt,Schefenacker
, p. 1254 - 1262 (2007/10/02)
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