80164-29-0

Upstream product

• 7536-61-0 N-(1,1-dimethylethoxycarbonyl)glycine 2,4,5-trichlorophenyl ester 
• 3982-71-6 N-benzyloxycarbonylglycyl-L-phenylalanyl-L-leucine methyl ester 
• 2666-93-5 (S)-Leu-OMe 
• 39621-73-3 N-t-butyloxycarbonylglycylglycyl-L-phenylalanine 
• 31972-52-8 Boc-Gly-Gly-OH 
• 68835-84-7 L-phenylalanyl-L-leucine methyl ester trifluoroacetate 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 4530-20-5 BOC-glycine 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 64152-76-7 methyl (S)-2-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropanamido)-4-methylpentanoate 
• 38155-19-0 L-phenylalanyl-L-leucine methyl ester 
• 63631-32-3 (S)-methyl 12-benzyl-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate 

Downstream Products

• 85541-25-9 N-benzyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine methyl ester 
• 1227828-36-5 N-Boc-4-(tributylstannyl)-L-phenylalanyl-glycylglycyl-L-phenylalanyl-L-leucine methyl ester 
• 68709-94-4 glycyl-glycyl-(S)phenylalanyl-(S)leucine methyl ester 
• 68835-86-9 Boc-L-Tyr-Gly-Gly-L-Phe-L-Leu-OMe 
• 88816-04-0 (S)-2-{(S)-2-[2-(2-Amino-thioacetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester 
• 88829-52-1 (S)-2-[(S)-2-(2-{2-[(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-thioacetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid methyl ester 
• 88815-99-0 (S)-2-{(S)-2-[2-(2-tert-Butoxycarbonylamino-thioacetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester 

Relevant academic research and scientific papers

An effective and safe enkephalin analog for antinociception

Opioids account for 69,000 overdose deaths per annum worldwide and cause serious side effects. Safer analgesics are urgently needed. The endogenous opioid peptide Leu-Enkephalin (Leu-ENK) is ineffective when introduced peripherally due to poor stability a

Practical Peptide Synthesis Mediated by a Recyclable Hypervalent Iodine Reagent and Tris(4-methoxyphenyl)phosphine

6-(3,5-Bis(trifluoromethyl)phenyl)-1H,4H-2aλ3-ioda-2,3-dioxacyclopenta[hi]indene-1,4-dione (p-BTFP-iodosodilactone, 1a) was synthesized and demonstrated to be an efficient hypervalent iodine(III) reagent for the synthesis of dipeptides from various standard amino acids, including sterically hindered amino acids, in good to high yields within 30 min in the presence of tris(4-methoxyphenyl)phosphine. In addition, the combined system of 1a/(4-MeOC6H4)3P was used to synthesize the pentapeptide leu-enkephalin in protected form. It is worth noting that 1a can be regenerated readily after reaction.

N-Triazinylammonium salts, a method of preparation and uses thereof

The invention provides inner quaternary N-triazinyl- ammonium salts of sulphonic acids, of the Formula 1, a method of preparation thereof and a use thereof as condensation reagents in condensation reactions.

Silver-catalyzed late-stage fluorination

Carbon-fluorine bond formation by transition metal catalysis is difficult, and only a few methods for the synthesis of aryl fluorides have been developed. All reported transition-metal-catalyzed fluorination reactions for the synthesis of functionalized arenes are based on palladium. Here we present silver catalysis for carbon-fluorine bond formation. Our report is the first example of the use of the transition metal silver to form carbon-heteroatom bonds by cross-coupling catalysis. The functional group tolerance and substrate scope presented here have not been demonstrated for any other fluorination reaction to date.

FLUORINATION OF ORGANIC COMPOUNDS

Methods for fluorinating organic compounds are described herein.

Selectivity in the Trimethylsilylation and Acylation of Peptide Bonds, and its Application to Modification of the Enkephalins

N.m.r. spectra of N-acylated peptides, formed by reaction of protected peptides with silylating agents followed by acylation, have provided a means for assessing selectivity in the acylation of amide bonds.Amino-acids such as valine and phenylalanine prev