68748-07-2

Usage

Uses

Used in Organic Synthesis:
N-(2-BROMO-4-ISOPROPYL-PHENYL)-ACETAMIDE is utilized as a synthetic intermediate for the preparation of a variety of organic compounds. Its unique structure allows for further chemical reactions, making it a versatile component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, N-(2-BROMO-4-ISOPROPYL-PHENYL)-ACETAMIDE is employed as a building block in the development of new drugs and therapeutic agents. Its chemical properties and reactivity contribute to the design and synthesis of potential pharmaceuticals, aiding in the advancement of medicinal chemistry.
Used in Medicinal Chemistry:
N-(2-BROMO-4-ISOPROPYL-PHENYL)-ACETAMIDE may have potential applications in the field of medicinal chemistry, where it could be instrumental in the discovery and development of novel drugs and therapeutic agents. Its structural features and chemical behavior are valuable in the creation of compounds with specific biological activities.
Used in Specialty Chemicals and Materials Manufacturing:
N-(2-BROMO-4-ISOPROPYL-PHENYL)-ACETAMIDE may also find uses in the manufacturing of specialty chemicals and materials, where its unique properties can be leveraged to produce high-value products with specific applications in various industries.

InChI:InChI=1/C11H14BrNO/c1-7(2)9-4-5-11(10(12)6-9)13-8(3)14/h4-7H,1-3H3,(H,13,14)

Upstream product

• 5702-74-9 N-(4-iso-propylphenyl)acetamide 
• 51605-97-1 2-bromo-4-isopropylaniline 
• 108-24-7 acetic anhydride 
• 99-88-7 4-Isopropylaniline 

Downstream Products

• 79069-38-8 2-(acetylamino)-5-(1-methylethyl)benzoic acid 
• 530403-36-2 N-[4-isopropyl-2-(dibenzoselenophene-4-yl)phenyl]acetamide 
• 880081-44-7 2-isopropenyl-4-isopropylaniline 
• 68701-44-0 2-cyano-4-isopropylacetanilide 
• 895239-75-5 (E)-3-(3-isopropylphenyl)acrylaldehyde 
• 457928-84-6 (S)-3-(3-isopropylphenyl)butanal 
• 880081-42-5 N-(2-isopropenyl-4-isopropyl-phenyl)-acetamide 

Relevant academic research and scientific papers

Site-Specific Synthesis of Carbazole Derivatives through Aryl Homocoupling and Amination

We synthesized various carbazoles from anilines through a three-step process with good overall yields (up to 48percent). This process comprises N -acetylation, copper(0)-mediated Ullmann homocoupling, and acid-mediated intramolecular amination. It permits various functional groups on the substrate. Scale-up of the developed three-step synthetic route to carbazoles was also demonstrated.

ARYL HYDROCARBON RECEPTOR (AHR) ACTIVATOR COMPOUNDS AS CANCER THERAPEUTICS

The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of cancers, particularly cancers that exhibit elevated expression of FOXA1 and/or FOXA1 gene targets, such as certain breast, liver and/or prostate cancers, including luminal and/or ER-positive forms of breast cancer. Three previously identified adenosine receptor antagonists, CGS-15943, MRS-1220 and SCH-58261, as well as furan ring moiety-possessing derivatives of CGS-15943 are specifically provided for killing cancer cells in a manner that appears to involve activation of the aryl hydrocarbon receptor (AHR) by such compounds. The instant disclosure therefore provides for selecting and/or administering CGS-15943, MRS-1220, SCH-58261 and/or a furan-possessing derivative of CGS-15943, MRS-1220 and/or SCH-58261 as a therapeutic agent to target a cancer cell and/or subject having or at risk of developing a cancer. Methods and compositions for therapies that include such compounds are also provided

A Visible Light-Mediated Regioselective Halogenation of Anilides and Quinolines by Using a Heterogeneous Cu-MnO Catalyst

A simple and practical heterogeneous Cu-MnO catalyzed regioselective halogenation of anilides and quinolines under irradiation with household 40 W incandescent lamp was developed. This method uses a recyclable Cu-MnO catalyst, acetonitrile as an industrially friendly solvent, and economic N-halo succinimides as a halogenating source. The reaction is scalable and well tolerated with a broad range of functional groups.

Copper-Catalyzed Enantioselective Conjugate Addition to α,β-Unsaturated Aldehydes with Various Organometallic Reagents

β-Substituted aldehydes constitute a very important class of compounds found in nature. Synthesis of this motif can be envisioned by C-C bond formation on enals. For this purpose, we report herein the development of enantioselective copper-catalyzed conjugate addition of various organometallic reagents to α,β-unsaturated aldehydes with (R)-H8BINAP, (R)-TolBINAP, and (R)-SEGPHOS as chiral ligands. Three sets of conditions were successfully developed and several enals were used. Reactivity and regio- and enantioselectivities were strongly dependent on reaction conditions and substrates. Good to excellent regio- and enantioselectivities were obtained with zinc reagents R2Zn and aluminum reagents R3Al. However, the asymmetric conjugate addition of Grignard reagents afforded only moderate to good regio- and enantioselectivities.

Sulfonamides having antiangiogenic and anticancer activity

Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.

Sulfonamides having antiangiogenic and anticancer activity

Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.

Sulfonamides having antiangiogenic and anticancer activity

Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating