5702-74-9

Basic information

• Product Name: 4-ISOPROPYLACETANILIDE
• Synonyms: 4-ISOPROPYLACETANILIDE;N-(4-ISOPROPYL-PHENYL)-ACETAMIDE;N1-(4-ISOPROPYLPHENYL)ACETAMIDE
• CAS NO: 5702-74-9
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.24
• Mol File: 5702-74-9.mol
• Article Data: 31

Chemical Properties

• Melting Point: 101-103°C
• Boiling Point: 323.7°Cat760mmHg
• Flash Point: 191.1°C
• Appearance: /
• Density: 1.026g/cm³
• Vapor Pressure: 3.11E-09mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-ISOPROPYLACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ISOPROPYLACETANILIDE(5702-74-9)
• EPA Substance Registry System: 4-ISOPROPYLACETANILIDE(5702-74-9)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 22-36/37/39
• Hazardous Substances Data: 5702-74-9(Hazardous Substances Data)

Usage

General Description

4-ISOPROPYLACETANILIDE, also known as 4-isopropylacetanilide or para-Isopropylacetanilide, is an organic compound with the chemical formula C11H15NO. It is a white, crystalline solid that is commonly used as an intermediate in the production of pharmaceuticals, particularly as an intermediate in the synthesis of the analgesic and antipyretic drug, acetaminophen (paracetamol). 4-ISOPROPYLACETANILIDE is also used in the cosmetic and personal care industry as an ingredient in hair and skin care products. The compound is known to have analgesic and anti-inflammatory properties, making it a valuable ingredient in various medicinal and cosmetic applications.

InChI:InChI=1/C16H18N2O3/c1-11-14(16(19)17-10-13-8-5-9-20-13)15(18-21-11)12-6-3-2-4-7-12/h2-4,6-7,13H,5,8-10H2,1H3,(H,17,19)

Upstream product

• 4218-48-8 1-ethyl-4-isopropylbenzene 
• 75-36-5 acetyl chloride 
• 2033-24-1 cycl-isopropylidene malonate 
• 99-88-7 4-Isopropylaniline 
• 2089-31-8 1-(4-isopropylphenyl)ethan-1-one oxime 
• 67-64-1 acetone 
• 108-05-4 vinyl acetate 
• 122-79-2 Phenyl acetate 
• 108-22-5 Isopropenyl acetate 
• 2161-86-6 2,4-diacetylphloroglucinol 
• 463302-31-0 para-isopropylphenyl isocyanide 
• 127-19-5 N,N-dimethyl acetamide 
• 123-54-6 acetylacetone 
• 1817-47-6 4-nitrocumene 

Downstream Products

• 400858-42-6 butyl(4-isopropylphenyl)amine 
• 895239-75-5 (E)-3-(3-isopropylphenyl)acrylaldehyde 
• 457928-84-6 (S)-3-(3-isopropylphenyl)butanal 
• 1401456-89-0 2-acetylamino-5-isopropylbenzoic acid ethyl ester 
• 328396-72-1 C₁₇H₁₈ClNO 
• 76842-12-1 N-(2-chloro-4-isopropylphenyl)acetamide 

Relevant articles and documents

Copper-promoted difunctionalization of unactivated alkenes with silanes

An efficient copper-catalyzed cascade difunctionalization of N-allyl anilines toward the synthesis of silylated indolines using commercially available silanes has been reported. This strategy provides a new avenue for the synthesis of a diverse array of i

Environmentally benign decarboxylative: N-, O-, and S-Acetylations and acylations

An operationally simple and general method for acetylation and acylation of a wide variety of substrates (amines, alcohols, phenols, thiols, and hydrazones) has been reported. Meldrum's acid and its derivatives have been used as an air-stable, non-volatile, cost-effective, and easy to handle acetylating/acylating agent. Easily separable byproducts (CO2 and acetone) allowed the isolation of analytically pure acetylated products without the requirement of work-up and any chromatography. This journal is

An organocatalytic C-C bond cleavage approach: A metal-free and peroxide-free facile method for the synthesis of amide derivatives

A facile organocatalytic approach has been devised towards the synthesis of amide derivatives using 1,3-dicarbonyls as easily available acyl-sources under peroxide-free reaction conditions. This transformation was accomplished by the cleavage of the C-C bond in the presence of TEMPO as an organocatalyst and excludes the use of transition-metals and harsh reaction conditions. A broad range of substrates with diverse functional groups were well tolerated and delivered the products in high yields.