68758-86-1

Basic information

• Product Name: methyl 4-(methylamino)-4-oxobutyrate
• Synonyms: methyl 4-(methylamino)-4-oxobutyrate;4-(Methylamino)-4-oxobutanoic acid methyl ester
• CAS NO: 68758-86-1
• Molecular Formula: C₆H₁₁NO₃
• Molecular Weight: 145.15644
• EINECS: 272-161-7
• Mol File: 68758-86-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 299.1°C at 760 mmHg
• Flash Point: 134.7°C
• Appearance: /
• Density: 1.059g/cm³
• Vapor Pressure: 0.00122mmHg at 25°C
• Refractive Index: 1.428
• CAS DataBase Reference: methyl 4-(methylamino)-4-oxobutyrate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(methylamino)-4-oxobutyrate(68758-86-1)
• EPA Substance Registry System: methyl 4-(methylamino)-4-oxobutyrate(68758-86-1)

Safety Data

• Hazardous Substances Data: 68758-86-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H11NO3/c1-7-5(8)3-4-6(9)10-2/h3-4H2,1-2H3,(H,7,8)

Upstream product

• 74-89-5 methylamine 
• 1490-25-1 succinic acid monomethylester chloride 
• 67-56-1 methanol 
• 56269-39-7 succinic acid-mono-N-methylamide 

Relevant articles and documents

Specificity of DNA alkylation by 1-(2-chloroethyl)-3-alkyl-3- acyltriazenes depends on the structure of the acyl group: Kinetic and product studies

The reactions of calf thymus DNA with ten 1-(2-chloroethyl)-3-alkyl-3- acyltriazenes of varying acyl side chain structure were studied alone, or in the presence of porcine liver esterase in pH 7.0 phosphate buffer. In several of the key triazenes, the acyl substituent contained a free carboxylic acid group. With esterase present in the reaction mixture, the resultant levels of DNA alkylation could be correlated with the kinetic rates of decomposition of the triazenes. Under these conditions, the predominant pathway of decomposition involved deacylation of the parent triazene and eventual production of an alkanediazonium ion. This intermediate subsequently alkylated DNA-guanine to give 7-alkylguanine as the principal reaction product. In the absence of esterase, the order of DNA alkylation for all of the acyltriazenes did not correlate with their respective rates of decomposition, leading to the conclusion that the triazenes did not decompose by the expected mode of uncatalyzed N(2)-N(3) heterolyic cleavage. The major DNA alkylation product from the N(3)-methyltriazenes was 7-methylguanine, instead of the expected 7-(chloroethyl)- and 7-(hydroxyethyl)guanine products, which suggested that the acyl group was being hydrolyzed. However, acyltriazenes with an N(3)-benzyl group rather than a methyl in this position produced very little 7-benzylguanine product, contrary to prediction. An alternative mechanism involving internally assisted hydrolysis of the side chain ester is proposed to explain these results. NMR product analysis and computational studies were carried out to lend support to the postulated mechanism.

KINETICS AND MECHANISM OF REVERSIBLE, BASE-CATALYSED RING CLOSURE OF 3-(METHOXYCARBONYL)PROPIONANILIDE AND O-(METHOXYCARBONYLMETHYL)-N-PHENYLCARBAMATE

The rate constants of reversible, base-catalysed ring closure of 3-(methoxycarbonyl)propionanilide (I) and O-(methoxycarbonylmethyl)-N-phenylcarbamate (II) to 1-phenyl-2,5-pyrrolidinedione (III) and 3-phenyl-2,4-oxazolidinedione (IV), respectively, and the rates of solvolyses of the cyclization products III and IV in water and methanol have been measured.In both cases, an equilibrium is established between the starting ester and the cyclization product in methoxide solutions which is strongly shifted in favour of the starting ester.In the case of ester II in methoxidesolutions, the cyclization is followed by a much slower splitting of the cyclization product to give glycolic acid anilide.The effects of the group X=NH, CH2, O, S in the esters RNHCOXCH2COOCH3 on the rates of the cyclization and solvolysis of the cyclization products is discussed.