68765-56-0

Upstream product

• 54231-32-2 3-chloro-2-nitropyridine 
• 54231-46-8 (2-nitro-pyridin-3-yl)-phenyl-amine 
• 54231-35-5 3-fuoro-2-nitropyridine 
• 62-53-3 aniline 
• 13534-99-1 2-Amino-3-bromopyridine 

Downstream Products

• 1393177-41-7 [(S)-1-(3-phenylaminopyridin-2-ylcarbamoyl)ethyl]carbamic acid tert-butyl ester 
• 1393177-42-8 [(S)-1-(1-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)ethyl]carbamic acid tert-butyl ester 
• 1393177-43-9 (S)-1-(1-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)ethylamine 
• 1393181-40-2 [1-(1-Phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-ethyl]-(9H-purin-6-yl)-amine 
• 1404086-73-2 9-((1-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)methyl)-9H-purin-6-amine 
• 1404086-74-3 6-((1-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)methylthio)-9H-purine 
• 1404085-63-7 (S)-N-(1-(1-Phenyl-1H-imidazo[4,5-b]pyridin-2-yl)ethyl)acetamide 
• 1404086-78-7 (S)-N-(1-(1-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)propyl)-9H-purin-6-amine 
• 1404085-69-3 (S)-1-(1-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)propan-1-amine 
• 1404085-68-2 (S)-tert-butyl 1-oxo-1-(3-(phenylamino)pyridin-2-ylamino)butan-2-ylcarbamate 
• 1404085-62-6 2-(chloromethyl)-1-phenyl-1H-imidazo[4,5-b]pyridine 

Relevant academic research and scientific papers

Imidazopyridine derivatives as PI3K inhibitors

New imidazopyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks)

IMIDAZOPYRIDINE DERIVATIVES AS PI3K INHIBITORS

New imidazopyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks).

HETEROCYCLIC COMPOUNDS AND METHODS OF USE

Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Palladium-Catalyzed C,N-Cross coupling reactions of 3-Halo-2-aminopyridines

A simple approach toward N3-substituted-2,3-diaminopyridines is presented, based on Pd-catalyzed C,N-cross coupling. The use of RuPhos- and BrettPhos-precatalysts in combination with LiHMDS allows for C,N-cross coupling reactions of unprotected