68768-34-3

Basic information

• Product Name: wyosine triacetate
• Synonyms: wyosine triacetate
• CAS NO: 68768-34-3
• Molecular Formula: C20H23N5O8
• Molecular Weight: 461.42532
• Mol File: 68768-34-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 727.8°Cat760mmHg
• Flash Point: 394°C
• Appearance: /
• Density: 1.57g/cm³
• Vapor Pressure: 4.89E-21mmHg at 25°C
• Refractive Index: 1.679
• CAS DataBase Reference: wyosine triacetate(CAS DataBase Reference)
• NIST Chemistry Reference: wyosine triacetate(68768-34-3)
• EPA Substance Registry System: wyosine triacetate(68768-34-3)

Safety Data

• Hazardous Substances Data: 68768-34-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H23N5O8/c1-9-6-24-18(29)14-17(23(5)20(24)22-9)25(8-21-14)19-16(32-12(4)28)15(31-11(3)27)13(33-19)7-30-10(2)26/h6,8,13,15-16,19H,7H2,1-5H3/t13-,15-,16-,19?/m1/s1

Upstream product

• 75-11-6 diiodomethane 
• 88094-82-0 6-methyl-3-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-4,9-dihydro-3H-imidazo[1,2-α]-purin-9-one 
• 1452798-29-6 2',3',5'-tri-O-acetyl-1-propargylguanosine 
• 6979-94-8 2',3',5'-tri-O-acetyl-guanosine 
• 74-88-4 methyl iodide 
• 52662-10-9 3,4-Dihydro-4,6-dimethyl-3-β-D-ribofuranosyl-9H-imidazo<1,2-a>purin-9-one 
• 108-24-7 acetic anhydride 

Downstream Products

• 52662-10-9 3,4-Dihydro-4,6-dimethyl-3-β-D-ribofuranosyl-9H-imidazo<1,2-a>purin-9-one 
• 35693-91-5 wybutine 
• 96881-39-9 7-methylwye 
• 108274-04-0 7-methyl-3-β-D-ribofuranosylwye 
• 1452798-34-3 (αS,βS)-α-[(methoxycarbonyl)amino]-β-(trimethylsilyloxy)-4,6-dimethyl-9-oxo-3-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-4,9-dihydro-3H-imidazo[1,2-α]purine-7-butanoic acid methyl ester 

Relevant articles and documents

Total synthesis of the hypermodified RNA bases wybutosine and hydroxywybutosine and their quantification together with other modified RNA bases in plant materials

We report an efficient synthesis of the hypermodified natural tRNA modifications wybutosine (yW) and hydroxywybutosine (OHyW). We also describe the preparation of isotopically labeled analogues for precise quantification of yW and OHyW in different tissue

AN EFFICIENT SYNTHESIS OF Y-NUCLEOSIDE (WYOSINE) BY REGIOSPECIFIC METHYLATION OF N4-DESMETHYLWYOSINE USING ORGANOZINC REAGENT

The reaction of the organozinc reagent, produced by the reaction of CH2I2 + Zn(C2H5)2 + glyme in diethylether at 20 deg C, regioselectively methylates the N4-nitrogen of N4-desmethylwyosine-triacetate 3 to give pure wyosine-triacetate 1e in 76percent isolated yield; no trace of the isomeric N5 methylated product is found in the latter reaction.Synthesis of a new congener of Y-nucleoside 1f is also reported for the first time from compound 5 in a high overall yield using a similar procedure.