68774-47-0

Upstream product

• 41107-82-8 2,5-anhydro-D-mannitol 
• 76-83-5 trityl chloride 
• 23261-20-3 1,2:5,6-dianhydrogalactitol 
• 1078691-95-8 (+)-D-glucosamine hydrochloride 
• 495-75-0 2,5-anhydro-D-mannose 

Downstream Products

• 149297-16-5 2,5-anhydro-3,4-O-(1,2-ethanediyl)-1,6-di-O-trityl-D-mannitol 
• 454474-65-8 (2R,3R,4R,5R)-3,4-di-tert-butyldimethylsilyloxy-2,5-bis(1-trityloxymethyl)tetrahydrofuran 
• 222555-96-6 2,5-anhydro-3,4-di-O-benzyl-D-mannitol 
• 220772-72-5 (2S,3R,4R,5R)-3,4-di-tert-butyldimethylsilyloxy-2-formyl-5-(1-trityloxymethyl)tetrahydrofuran 
• 220772-71-4 (2R,3R,4R,5R)-3,4-di-tert-butyldimethylsilyloxy-5-(hydroxymethyl)-2-(1-trityloxymethyl)tetrahydrofuran 
• 220772-74-7 (2R,3R,4R,5R)-3,4-di-tert-butyldimethylsilyloxy-2-[(1S)-(1-hydroxy)ethynyl]-5-(1-trityloxymethyl)tetrahydrofuran 
• 220772-75-8 (2R,3R,4R,5R)-3,4-di-tert-butyldimethylsilyloxy-2-[(1S)-(1-methoxymethyloxy)ethynyl]-5-(1-trityloxymethyl)tetrahydrofuran 
• 220772-81-6 (2S,5S,6S,9S,10S,13R,14S)-2,5:10,14-dioxido-6,9,13-tris(methoxymethoxy)-1-trityloxytetracos-3-ene 
• 454474-70-5 (2S,5S,6S,9S,10S,13R,14S)-2,5:10,14-dioxido-6,9,13-tris(methoxymethoxy)-1-trityloxytetracosane 
• 220772-79-2 (2R,3S,4S,5S,6S,9S,10S,13R,14S)-2,5:10,14-dioxido-6,9,13-tris(methoxymethoxy)-1-trityloxytetracosane-3,4-diol 
• 220772-80-5 (2R,3R,4R,5R,6S,9S,10S,13R,14S)-2,5:10,14-dioxido-3,4-bis(methanesulfonyloxy)-6,9,13-tris(methoxymethoxy)-1-trityloxytetracosane 
• 220772-77-0 (2R,3R,4R,5R,6S,9S,10S,13R,14S)-3,4-bis(tert-butyldimethylsilyloxy)-2,5:10,14-dioxido-6,13-bis(methoxymethoxy)-1-trityloxytetracosan-9-ol 
• 220772-76-9 (2R,3R,4R,5R,6S,9RS,10S,13R,14S)-3,4-bis(tert-butyldimethylsilyloxy)-2,5:10,14-dioxido-6,13-bis(methoxymethoxy)-1-trityloxytetracos-7-yn-9-ol 
• 454475-02-6 (S)-4-[(2R,3R,4R,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-1-((2S,5R,6S)-6-decyl-5-methoxymethoxy-tetrahydro-pyran-2-yl)-4-methoxymethoxy-butan-1-ol 

Relevant academic research and scientific papers

Synthesis of poly-O-sulfated glycosides of 2,5-anhydro-D-mannitol

2,5-Anhydro-3-O-β-d-glucopyranosyl-; -3-O-α-l-idopyranosyl-; -3-O-α-d-arabinopyranosyl-; -3-O-α-l-arabinopyranosyl-; -3-O-β-d-maltopyranosyl-; -3-O-β-d-gentiobiopyranosyl-; -1,6-di-O-β-d-glucopyranosyl-; -1,6-di-O-α-l-idopyranosyl-; -1-O-β-d-maltopyranosy

Chiral diphosphorus compounds and their transition metal complexes

The present invention relates to chiral diphosphorus compounds and their transition metal complexes, to a process for preparing chiral diphosphorus compounds and their transition metal complexes and also to their use in asymmetric syntheses.

Chiral diphosphorus compounds and transition metal complexes thereof

Tetrahydrofuran bisphosphines of formula (I), are new. Tetrahydrofuran bisphosphines of formula (I): X1, X2 = bonds or O; R1, R2 = H, 1-20C alkyl, 1-20C fluoroalkyl, 2-20C alkenyl, 4-24C aryl, 5-25C aralkyl, 6-26C aralkenyl, NR7R8, OR8, AOR8, ANR7R8 or OC

Total synthesis of an antitumor agent, mucocin, based on the "chiron approach"

The total synthesis of a powerful antitumor acetogenin, mucocin (1), was achieved through a palladium-catalyzed cross-coupling reaction of the THP-THF fragment 2 and a terminal butenolide 3. The key process for construction of the fragment 2 was chelation-controlled addition of ethynylmagnesium chloride to disilyl aldehyde 23a and condensation of the alkyllithium prepared therefrom with THP aldehyde 4 in the presence of CeCl3. Synthesis of the lactone 3 relied on a novel approach by taking advantage of a radical cyclization of acyclic selenocarbonate 6. The three building blocks 4, 5a, and 6 were prepared stereoselectivly from D-galactose (7), 2,5-anhydro-D-mannitol (8), and L-rhamnose (9), respectively. A new and efficient method for desymmetrization of the C2-symmetrical compound 8 is also described.

Stereoselective synthesis of the 3-hydroxytetrahydropyran part of mucocin, an antitumor agent, based on rearrangement-ring expansion reaction of a tetrahydrofuran derivative

The synthesis of the 2,6-disubstituted 2,3-trans-3- hydroxytetrahydropyran part of mucocin, a potent antitumor agent, was accomplished based on the zinc acetate-induced ring expansion reaction of a tetrahydrofuran having a choloromethanesulfonate on the C

Synthesis of 3-deoxy-3-nucleobase-2,5-anhydro-D-mannitol: A novel class of hydroxymethyl-branched isonucleosides

A concise synthesis of 3-deoxy-3-nucleobase-2,5-anhydro-D-mannitol 6(a- d) has been achieved, using the deamination of 2-amino-2-deoxy-D-glucose to construct in one step the sugar skeleton with the desired sense of chirality at each asymmetric center. The selective dibenzoylation of 2,5-anhydro-D- mannitol 9 was investigated, and the key epoxide intermediate 13 was obtained in good yield via an intramolecular Mitsunobu reaction. The process of opening of epoxide 13 by nucleobases appeared to be regioselective. (C) 2000 Elsevier Science Ltd.

THE CHEMICAL-TRANSFORMATION PRODUCTS OF 1,6-DIBROMO-1,6-DIDEOXYGALACTITOL AND 1,2:5,6-DIANHYDROGALACTITOL IN AQUEOUS SOLUTION

After hydrolysis of 1,6-dibromo-1,6-dideoxygalactitol (1) and 1,2:5,6-dianhydrogalactitol (2), 11 compounds were isolated, three of them as tritylated derivatives.Their structures were established on the basis of chemical evidence and, for four compounds, by X-ray diffraction.The main product of the hydrolysis of 1 was 3,6-anhydro-1-bromo-1-deoxy-DL-galactitol; the end-products of the hydrolysis of 2 were 1,5-anhydro-DL-galactitol, 2,5-anhydro-DL-altriol and galactiotol.