68819-83-0

Basic information

• Product Name: methyl N-(4-bromobenzyl)carbamate
• Synonyms: methyl N-(4-bromobenzyl)carbamate
• CAS NO: 68819-83-0
• Molecular Weight: 244.088
• Mol File: 68819-83-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl N-(4-bromobenzyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl N-(4-bromobenzyl)carbamate(68819-83-0)
• EPA Substance Registry System: methyl N-(4-bromobenzyl)carbamate(68819-83-0)

Safety Data

• Hazardous Substances Data: 68819-83-0(Hazardous Substances Data)

Upstream product

• 16532-79-9 4-Bromophenylacetonitrile 
• 67-56-1 methanol 
• 74860-13-2 4-bromobenzeneacetamide 
• 3959-07-7 4-Bromobenzylamine 
• 79-22-1 methyl chloroformate 
• 1122-91-4 4-bromo-benzaldehyde 
• 598-55-0 methyl carbamate 
• 66389-77-3 methyl tert-butyl iminodicarboxylate potassium salt 
• 589-15-1 1-bromomethyl-4-bromobenzene 

Downstream Products

• 3959-07-7 4-Bromobenzylamine 

Relevant articles and documents

Hypervalent iodine catalyzed hofmann rearrangement of carboxamides using oxone as terminal oxidant

Hofmann rearrangement of carboxamides to carbamates using Oxone as an oxidant can be efficiently catalyzed by iodobenzene. This reaction involves hypervalent iodine species generated in situ from catalytic amount of PhI and Oxone in the presence of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) in aqueous methanol solutions. Under these conditions, Hofmann rearrangement of various carboxamides affords corresponding carbamates in high yields.

Rapid and convenient microwave-assisted synthesis of primary amines via reductive N-alkylation of methyl carbamate with aldehydes

Microwave-assisted reductive alkylation of methyl carbamate with a range of aldehydes provides, after basic work-up, an experimentally simple, one-pot method for rapid functional group interconversion of structurally diverse aldehydes into primary amines. The method has several advantages over more traditional methods of carrying out this transformation and is particularly amenable to high-throughput synthesis.