688362-46-1

Basic information

• Product Name: N-(1-(4-bromophenyl)prop-2-yn-1-yl)acetamide
• Synonyms: N-(1-(4-bromophenyl)prop-2-yn-1-yl)acetamide
• CAS NO: 688362-46-1
• Molecular Weight: 252.11
• Mol File: 688362-46-1.mol

Chemical Properties

• CAS DataBase Reference: N-(1-(4-bromophenyl)prop-2-yn-1-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-(4-bromophenyl)prop-2-yn-1-yl)acetamide(688362-46-1)
• EPA Substance Registry System: N-(1-(4-bromophenyl)prop-2-yn-1-yl)acetamide(688362-46-1)

Safety Data

• Hazardous Substances Data: 688362-46-1(Hazardous Substances Data)

Upstream product

• 75-05-8 acetonitrile 
• 85020-75-3 1-(4-bromophenyl)-2-propyn-1-ol 

Downstream Products

• 688362-60-9 (+/-)-1-(4-bromophenyl)-2-propenylamine 
• 949587-97-7 (R)-N-[(1-benzyl-1H-[1,2,3]triazol-4-yl)-(4-bromophenyl)-methyl]amine 
• 949587-96-6 (R)-N-[4-bromophenyl-(1-phenyl-1H-[1,2,3]triazol-4-yl)-methyl]amine 
• 951387-14-7 1-(4-bromophenyl)prop-2-yn-1-amine 
• 688362-53-0 (+/-)-N-1-acetyl-1-(4-bromophenyl)-2-propenylamine 

Relevant articles and documents

Synthesis of enantiomerically pure α-[4-(1-substituted)-1,2,3-triazol-4-yl]-benzylacetamides via microwave-assisted click chemistry: towards new potential antimicrobial agents

Chiral 1-phenyl-2-propynylamines are important building blocks for the synthesis of antifungal and antiaromatase agents related to bifonazole. In this report, a microwave-assisted Cu(I)-catalyzed 'click chemistry' approach has been employed to easily generate a small library of enantiomerically pure α-[4-(1-substituted)-1,2,3-triazol-4-yl]benzylacetamides starting from racemic propargylamines. These compounds could represent easily accessible intermediates for the synthesis of new antimicrobial agents.

SUBSTITUTED PYRAZOLOPYRIMIDINES AND SUBSTITUTED PURINES AND THEIR USE AS UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 1 (USP1) INHIBITORS

The present disclosure provides compounds having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein X1, X2, X11, X12, R1, R3, R5, R5', R6, and R7 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to inhibit a USP1 protein and/or to treat a disorder responsive to the inhibition of USP1 proteins and USP1 activity. Compounds of the present disclosure are especially useful for treating cancer.

Enantioselective synthesis of 1-aryl-2-propenylamines: A new approach to a stereoselective synthesis of the Taxol side chain

A variety of substituted 1-aryl-2-propenylamines of high enantiomeric purity were prepared via lipase-catalysed resolution of the corresponding racemates. (R)-1-Phenyl-2-propenylamine was further synthesised into (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoic acid methyl ester, the side chain of Taxol.