688362-68-7

Upstream product

• 4393-21-9 1-(phenyl)allylamine 
• 141-78-6 ethyl acetate 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 59874-90-7 N-<1-(1-phenylprop-2-enyl)> trichloroacetamide 
• 59874-81-6 1-(1-imino-2,2,2-trichloroethoxy)-3-phenyl-2(E)-propene 
• 108-21-4 Isopropyl acetate 
• 154614-38-7 (+/-)-N-1-acetyl-1-phenyl-2-propenylamine 
• 123772-66-7 N-(α-phenylpropargyl)acetamide 
• 676268-38-5 (1S,1'S)-(-)-N-(1-phenylbutoxy)-3-phenyl-3-prop-1-enylamine 
• 260998-33-2 (E)-(S)-(-)-O-(1-phenylbutyl) benzaldehyde oxime 
• 108-24-7 acetic anhydride 

Downstream Products

• 688362-39-2 N-[(1R)-1-phenylprop-2-en-1-yl]benzamide 
• 103150-32-9 (1S,2R)-N-1-(1-phenyl-2,3-dihydroxypropyl)benzamide 
• 325490-29-7 (1R)-1-phenylprop-2-en-1-amine 

Relevant academic research and scientific papers

Enantioseparation, in vitro testing, and structural characterization of triple-binding reactivators of organophosphate-inhibited cholinesterases

The enantiomers of racemic 2-hydroxyimino-N-(azidophenylpropyl)acetamide-derived triple-binding oxime reactivators were separated, and tested for inhibition and reactivation of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibited with ta

An efficient enzymatic approach to (S)-1-aryl-allylamines

A range of 1-aryl-allylamines were prepared in moderate to excellent enantioselectivity (ee 63.5%→99.9%) using lipase B from a Candida antarctica catalyzed resolution of racemic amines. This is the first time that CaLB has been used for the resolution of 1-aryl-allylamines. Racemic amines were prepared starting from aromatic aldehydes with a [3,3]-sigmatropic rearrangement of the acyclic imidates as the key step followed by trichloroacetamidate hydrolysis. Aldehydes were converted into acrylic esters using Knoevenagel reaction. After reduction, the corresponding alcohols were used for the preparation of trichloroacetimidates, which were then used in an Overman rearrangement.

Enantioselective synthesis of 1-aryl-2-propenylamines: A new approach to a stereoselective synthesis of the Taxol side chain

A variety of substituted 1-aryl-2-propenylamines of high enantiomeric purity were prepared via lipase-catalysed resolution of the corresponding racemates. (R)-1-Phenyl-2-propenylamine was further synthesised into (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoic acid methyl ester, the side chain of Taxol.

Asymmetric synthesis of N-protected amino acids by the addition of organolithium carboxyl synthons to ROPHy/SOPHy-derived aldoximes and ketoximes.

A new asymmetric synthesis of alpha-amino acids is described in which the key step is the highly diastereoselective addition of organolithium carboxyl synthons (2-furyllithium, phenyllithium, vinyllithium) to (R)- and (S)-O-(1-phenylbutyl) oximes to give hydroxylamines, with vinyllithium being the most satisfactory nucleophilic reagent. Subsequent reductive cleavage of the N-O bond in hydroxylamines, followed by N-protection, and oxidative cleavage of the carboxyl precursor gave a range of N-protected amino acids and esters. The method was exemplified by the synthesis of a range of derivatives of non-proteinogenic amino acids such as 4-bromophenylalanine, tert-leucine, norvaline, cyclohexyl- and aryl-glycines, 2-amino-8-oxodecanoic acid (Aoda) and alpha-methylvaline.