68840-81-3

Upstream product

• 3338-08-7 2-benzyl-3,4,5,6-tetrahydro-2H-azepin 
• 154188-72-4 7-phenylhept-6-yn-1-amine 
• 62596-18-3 7-benzylazepan-2-one 
• 111-49-9 hexamethylene imine 
• 946-33-8 2-benzylcyclohexan-1-one 
• 2214-81-5 tetrahydroazepine 
• 6921-34-2 benzylmagnesium chloride 
• 114635-55-1 C₁₉H₂₂N₂O₅S 
• 114635-72-2 N-(1-benzylcyclohexyl)hydroxylamine 
• 70367-75-8 1-benzyl-1-nitrocyclohexane 
• 19165-94-7 1-benzylcyclohexan-1-amine 

Downstream Products

• 114635-83-5 1-(p-nitrobenzoyl)-2-benzylazacycloheptane 
• 68840-95-9 2-benzyl-1-methyl-azepane 
• 68840-87-9 2-(4-nitrobenzyl)perhydroazepine 

Relevant academic research and scientific papers

ATM KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

Provided are certain ATM kinase inhibitors of Formula (I). Also provided herein are compositions of such compounds, and methods of their use.

α-Functionalization of Cyclic Secondary Amines: Lewis Acid Promoted Addition of Organometallics to Transient Imines

Cyclic imines, generated in situ from their corresponding N-lithiated amines and a ketone hydride acceptor, undergo reactions with a range of organometallic nucleophiles to generate α-functionalized amines in a single operation. Activation of the transient imines by Lewis acids that are compatible with the presence of lithium alkoxides was found to be crucial to accommodate a broad range of nucleophiles including lithium acetylides, Grignard reagents, and aryllithiums with attenuated reactivities.

Pd(OAc)2-catalyzed carbonylation of amines

A phosphine-free catalytic system [Pd(OAc)2-Cu(OAc) 2-air] induced a substrate-specific carbonylation of amines in boiling toluene under CO gas (1 atm). Symmetrical N,N′-dialkylureas were obtained by the carbonylation of primary amines. N,N,N′-Trialkylureas were selectively formed by addition of a secondary amine to the above reaction vessel. Secondary amines did not give tetraalkylureas. However, dialkylamines with a phenyl group on their alkyl chains, such as N-monoalkylated benzylic amine or phenethylamine derivatives, underwent a direct aromatic carbonylation to afford five- or six-membered benzolactams. In the carbonylation, the chelation effect or steric repulsion between Pd(II) and the meta-substituent in the ortho-palladation and the ring sizes of cyclopalladation products that were formed prior to carbonylation were found to generate good site selectivity and increase the reaction rate. In contrast, carbonylation of ω- arylalkylamines with a hydroxyl group gave neither ureas nor benzolactams but instead produced 1,3-oxazolidinones smoothly. Hydrochlorides of amines also underwent carbonylation to afford the corresponding amides under the conditions used. This procedure made it possible to prepare ureas of amino acid esters and N-alkylcarbamates in practical yields.

Ruthenium-catalyzed intramolecular hydroamination of aminoalkynes

Low-valent ruthenium complexes with a π-acidic ligand, such as Ru(η6-cot)(dmfm)2 [cot=1,3,5-cyclooctatriene, dmfm=dimethyl fumarate] and Ru3(CO)12, showed high catalytic activity for the intramolecular hydroamination of aminoalkynes. The reaction is highly regioselective, in which a nitrogen atom is selectively attached to an internal carbon of alkynes to give five-, six-, and seven-membered nitrogen heterocycles as well as indoles in good to high yields.

Carbon-to-Nitrogen Rearrangement in N-(Arylsulfonoxy)amines as a Route to Azacyclic Compounds

A series of cyclic amines 1-10 was converted to the N-((p-nitrophenyl)sulfonoxy)amine derivatives with (p-nitrophenyl)sulfonyl peroxide.These compounds rearranged to ring-expanded cyclic imines in fair to good yields.Conversion of the amine to its hydroxy

2-(Optionally-substituted)benzylperhydroazepines for analgesia and lowering blood pressure

Title compounds and their acid-addition salts are physiologically acceptable or are readily converted to physiologically-acceptable counterparts by established procedures. They are pharmacologically active on the central nervous system (CNS) and are thus useful, when administered to warm-blooded animals, to induce central stimulation, to increase vigilance and to promote normal and pathologically-inhibited drive. They are also useful as analgesics and as blood-pressure-reducing agents for warm-blooded animals. These compounds are prepared, e.g., by reducing an appropriate 2-benzylazacycloheptane and are compounded into normal dosage-form medicament compositions.