19165-94-7

Basic information

• Product Name: Cyclohexanamine, 1-(phenylmethyl)-
• CAS NO: 19165-94-7
• Molecular Formula: C13H19N
• Molecular Weight: 189.301
• Mol File: 19165-94-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Cyclohexanamine, 1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanamine, 1-(phenylmethyl)-(19165-94-7)
• EPA Substance Registry System: Cyclohexanamine, 1-(phenylmethyl)-(19165-94-7)

Safety Data

• Hazardous Substances Data: 19165-94-7(Hazardous Substances Data)

Upstream product

• 7647-01-0 hydrogenchloride 
• 408314-95-4 (1-amino-cyclohexyl)-(4-amino-phenyl)-methane 
• 1608-31-7 (cyclohexylidenemethyl)benzene 
• 108-91-8 cyclohexylamine 
• 108-94-1 cyclohexanone 
• 1589-82-8 phenylmagnesium bromide 
• 1944-01-0 1-benzylcyclohexan-1-ol 

Downstream Products

• 114635-83-5 1-(p-nitrobenzoyl)-2-benzylazacycloheptane 
• 68840-81-3 2-benzylhexahydroazepine 
• 3338-08-7 2-benzyl-3,4,5,6-tetrahydro-2H-azepin 
• 19165-97-0 N-(1-benzylcyclohexyl)benzamide 
• 114635-55-1 C₁₉H₂₂N₂O₅S 

Relevant articles and documents

Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination

Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal-free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α-branched, and α-tertiary primary amines under mild conditions. This method provides a straightforward and powerful approach to a wide spectrum of advanced, highly functionalized primary amines which are of particular interest in pharmaceutical chemistry and other areas.

Synthesis and Anticonvulsant Activity of 1-Phenylcyclohexylamine Analogues

Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a motor-toxicity assay.In addition, we determined the binding affinities of the compounds for PCP acceptor sites in rat brain membranes labeled with -1-piperidine.Many of the analogues were protective against MES seizures (ED50s of 4-41 mg/kg, ip) and all of these compounds caused motor toxicity.The potencies in the motor toxicity and MES seizure tests showed a moderate correlation with the affinities for PCP sites.Several analogues exhibited a greater separation of potencies in the motor toxicity and MES seizure tests than did the parent compound PCA.These were obtained by (i) 3-methylation of the cyclohexyl ring trans to the phenyl ring, (ii) methoxylation at the ortho position on the phenyl ring, and (iii) contraction of the cyclohexane ring to form the corresponding cyclopentane.